Ubiquitin-proteasome mediated protein turnover is an important regulatory mechanism of
cellular function in eukaryotes. Extensive studies have linked the ubiquitin-proteasome …

Posttranslational modifications of proteins drive a wide variety of cellular processes in
eukaryotes, regulating cell growth and division as well as adaptive and developmental …

Cryptococcus neoformans is a ubiquitous human fungal pathogen. This pathogen can
undergo morphotype transition between the yeast and the filamentous form and such …

Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal
meningitis in immunocompromised individuals. Treatment options for cryptococcosis are …

Echinocandins show fungicidal activity against common invasive mycoses but are ineffective
against cryptococcosis. The underlying mechanism for echinocandin resistance in …

F-box proteins share the F-box domain to connect substrates of E3 SCF ubiquitin RING
ligases through the adaptor Skp1/A to Cul1/A scaffolds. F-box protein Fbx15 is part of the …

Cryptococcus neoformans is a fungal pathogen that infects the lungs and then often
disseminates to the central nervous system, causing meningitis. How Cryptococcus is able …

Eukaryotic cells have evolved mechanisms to sense and adapt to dynamic environmental
changes. Adaptation to thermal insults, in particular, is essential for their survival. The major …

The ubiquitin-proteasome system is one of the major protein turnover mechanisms that plays
important roles in the regulation of a variety of cellular functions. It is composed of E1 …

Summary The Skp1‐Cul1‐F‐box‐protein (SCF) ubiquitin ligases are important parts of the
ubiquitin system controlling many cellular biological processes in eukaryotes. However, the …