Overweight and obesity are associated with several cardiometabolic risk factors, including
insulin resistance, type 2 diabetes, low-grade inflammation and liver diseases. The gut …

Despite intensive studies for decades, the common mechanistic correlations among the
underlying pathology of diabetes mellitus (DM), its complications, and effective clinical …

The antidiabetic drug metformin has been proposed to affect non-alcoholic fatty liver disease
(NAFLD) through its effects on intestinal microbiota and barrier function. However, so far …

Methylation of nuclear genes encoding mitochondrial proteins participates in the regulation
of mitochondria function. The existence of cytosine methylation in the mitochondrial genome …

Objective Given that cellular O-GlcNAcylation levels are thought to be real-time measures of
cellular nutrient status and dysregulated O-GlcNAc signaling is associated with insulin …

Given the growing evidence that gut dysfunction, including changes in gut microbiota
composition, plays a critical role in the development of inflammation and metabolic …

Colitis is characterized by colonic inflammation and impaired gut health. Both features
aggravate obesity and insulin resistance. Host defense peptides (HDPs) are key regulators …

Objectives GPR142, which is highly expressed in pancreatic islets, has recently been
deorphanized as a receptor for aromatic amino acids; however, its physiological role and …

Skeletal muscle is the key tissue for maintaining protein and glucose homeostasis, having a
profound impact on the development of diabetes. Diabetes causes deleterious changes in …

Background Universally accepted therapeutic strategies for the treatment of nonalcoholic
steatohepatitis (NASH) are still lacking. Studies suggest a preventive effect of oral Gln …