[HTML][HTML] Advances in biomedical functions of natural whitening substances in the treatment of skin pigmentation diseases

F Liu, L Qu, H Li, J He, L Wang, Y Fang, X Yan, Q Yang… - Pharmaceutics, 2022 - mdpi.com
Pigmentation diseases can lead to significant color differences between the affected part
and the normal part, resulting in severe psychological and emotional distress among …

[HTML][HTML] Anti-melanogenic potential of natural and synthetic substances: application in zebrafish model

AM Ferreira, AA de Souza, RCR Koga, IS Sena… - Molecules, 2023 - mdpi.com
Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human
skin. A key enzyme in the process of pigmentation through melanin is tyrosinase, which …

[HTML][HTML] Improving tyrosinase inhibitory activity of grass carp fish scale gelatin hydrolysate by gastrointestinal digestion: Purification, identification and action …

ZZ Hu, TX Ma, XM Sha, L Zhang, ZC Tu - Lwt, 2022 - Elsevier
Biologically active peptides with tyrosinase inhibitory activity may be important raw materials
in the field of whitening foods. Gastrointestinal digestion was employed to obtain …

Inhibition of α-melanocyte-stimulating hormone-induced melanogenesis and molecular mechanisms by polyphenol-enriched fraction of Tagetes erecta L. flower

SS Sanjaya, MH Park, WAHM Karunarathne, KT Lee… - Phytomedicine, 2024 - Elsevier
Background The pursuit for safe and efficacious skin-whitening agents has prompted a
dedicated exploration of plant-derived compounds. Notably, Tagetes erecta L. flowers have …

Medicinal prospects of targeting tyrosinase: A feature review

Y Wang, B Xiong, S Xing, Y Chen… - Current Medicinal …, 2023 - ingentaconnect.com
Tyrosinase is a bifunctional polyphenol oxidase (PPO), catalyzing two oxidative reactions:
monophenols to o-quinones (monophenolase activity) and o-diphenols to oquinones …

[HTML][HTML] Sesamol inhibited melanogenesis by regulating melanin-related signal transduction in B16F10 cells

PY Wu, YJ You, YJ Liu, CW Hou, CS Wu… - International journal of …, 2018 - mdpi.com
Melanin is synthesized through a series of interactions catalyzed by melanogenic enzymes
such as tyrosinase, dopachrome tautomerase (tyrosinase-related protein-2; TRP-2), and …

[HTML][HTML] Sesamol inhibited ultraviolet radiation-induced hyperpigmentation and damage in C57BL/6 mouse skin

YJ You, PY Wu, YJ Liu, CW Hou, CS Wu, KC Wen… - Antioxidants, 2019 - mdpi.com
Melanin is synthesized through a series of oxidative reactions initiated with tyrosine and
catalyzed by melanogenesis-related proteins such as tyrosinase, tyrosinase-related protein …

Melanins as sustainable resources for advanced biotechnological applications

HA Galeb, EL Wilkinson, AF Stowell, H Lin… - Global …, 2021 - Wiley Online Library
Melanins are a class of biopolymers that are widespread in nature and have diverse origins,
chemical compositions, and functions. Their chemical, electrical, optical, and paramagnetic …

Design, synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors

Z Sheng, S Ge, X Xu, Y Zhang, P Wu, K Zhang, X Xu… - …, 2018 - pubs.rsc.org
Tyrosinase is a key enzyme in melanin biosynthesis, and is also involved in the enzymatic
browning of plant-derived foods. Tyrosinase inhibitors are very important in medicine …

[HTML][HTML] Mechanism, Formulation, and Efficacy Evaluation of Natural Products for Skin Pigmentation Treatment

X Peng, Y Ma, C Yan, X Wei, L Zhang, H Jiang, Y Ma… - Pharmaceutics, 2024 - mdpi.com
Skin pigmentation typically arises from the excessive secretion and accumulation of
melanin, resulting in a darker complexion compared to normal skin. Currently, the local …