Targeting innate immunity-driven inflammation in CKD and cardiovascular disease

T Speer, S Dimmeler, SJ Schunk, D Fliser… - Nature Reviews …, 2022 - nature.com
Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Pharmacological therapeutics targeting RNA-dependent RNA polymerase, proteinase and spike protein: from mechanistic studies to clinical trials for COVID-19

J Huang, W Song, H Huang, Q Sun - Journal of clinical medicine, 2020 - mdpi.com
An outbreak of novel coronavirus-related pneumonia COVID-19, that was identified in
December 2019, has expanded rapidly, with cases now confirmed in more than 211 …

Review on inflammation markers in chronic kidney disease

T Petreski, N Piko, R Ekart, R Hojs, S Bevc - Biomedicines, 2021 - mdpi.com
Chronic kidney disease (CKD) is one of the major health problems of the modern age. It
represents an important public health challenge with an ever-lasting rising prevalence …

Lipoproteins in chronic kidney disease: from bench to bedside

T Speer, PM Ridker, A von Eckardstein… - European Heart …, 2021 - academic.oup.com
Chronic kidney disease (CKD) is associated with high cardiovascular risk. CKD patients
exhibit a specific lipoprotein pattern termed 'uraemic dyslipidaemia', which is characterized …

Tissue sodium accumulation induces organ inflammation and injury in chronic kidney disease

Y Ito, T Sun, H Tanaka, M Yamaguchi… - International Journal of …, 2023 - mdpi.com
High salt intake is a primary cause of over-hydration in chronic kidney disease (CKD)
patients. Inflammatory markers are predictors of CKD mortality; however, the pathogenesis …

The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

WW Cheung, R Zheng, S Hao, Z Wang, A Gonzalez… - Scientific Reports, 2021 - nature.com
Cytokines such as IL-6, TNF-α and IL-1β trigger inflammatory cascades which may play a
role in the pathogenesis of chronic kidney disease (CKD)-associated cachexia. CKD was …

Current understanding of the relationship of HDL composition, structure and function to their cardioprotective properties in chronic kidney disease

G Marsche, GH Heine, JT Stadler, M Holzer - Biomolecules, 2020 - mdpi.com
In the general population, the ability of high-density lipoproteins (HDLs) to promote
cholesterol efflux is a predictor of cardiovascular events, independently of HDL cholesterol …

Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: a new paradigm for drug discovery

J Huang, D Wang, LH Huang, H Huang - International journal of …, 2020 - mdpi.com
Epidemiological results revealed that there is an inverse correlation between high-density
lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease …

Interleukin-6 blockade reduces salt-induced cardiac inflammation and fibrosis in subtotal nephrectomized mice

H Tanaka, T Sun, H Kinashi, K Kamiya… - American Journal …, 2022 - journals.physiology.org
Cardiovascular disease is the most common comorbidity in patients with chronic kidney
disease (CKD), affecting both their prognosis and quality of life. Cardiac fibrosis is common …

Inflammation, lymphatics, and cardiovascular disease: amplification by chronic kidney disease

V Kon, EL Shelton, A Pitzer, HC Yang… - Current hypertension …, 2022 - Springer
Abstract Purpose of Review Kidney disease is a strong modulator of the composition and
metabolism of the intestinal microbiome that produces toxins and inflammatory factors. The …