On the lineage of Aspergillus fumigatus isolates in common laboratory use

M Bertuzzi, N Van Rhijn, S Krappmann… - Medical …, 2021 - academic.oup.com
The origin of isolates routinely used by the community of Aspergillus fumigatus researchers
is periodically a matter of intense discussion at our centre, as the construction of …

Pyroptosis: The missing puzzle among innate and adaptive immunity crosstalk

MY Hachim, BA Khalil, NM Elemam… - Journal of Leucocyte …, 2020 - academic.oup.com
Pyroptosis is a newly discovered programmed cell death with inflammasome formation.
Pattern recognition receptors that identify repetitive motifs of prospective pathogens such as …

The pan-genome of Aspergillus fumigatus provides a high-resolution view of its population structure revealing high levels of lineage-specific diversity driven by …

LA Lofgren, BS Ross, RA Cramer, JE Stajich - PLoS Biology, 2022 - journals.plos.org
Aspergillus fumigatus is a deadly agent of human fungal disease where virulence
heterogeneity is thought to be at least partially structured by genetic variation between …

Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing

EE Rosowski, N Raffa, BP Knox, N Golenberg… - PLoS …, 2018 - journals.plos.org
In immunocompromised individuals, Aspergillus fumigatus causes invasive fungal disease
that is often difficult to treat. Exactly how immune mechanisms control A. fumigatus in …

Immunity to pathogenic fungi in the eye

S Abbondante, SM Leal, HL Clark, B Ratitong… - Seminars in …, 2023 - Elsevier
Abstract Fusarium, Aspergillus and Candida are important fungal pathogens that cause
visual impairment and blindness in the USA and worldwide. This review will summarize the …

Pathogenic Aspergillus and Fusarium as important causes of blinding corneal infections—the role of neutrophils in fungal killing, tissue damage and cytokine …

B Ratitong, E Pearlman - Current opinion in microbiology, 2021 - Elsevier
Filamentous fungi Aspergillus and Fusarium species are major causes of visual impairment
and blindness in immune competent individuals. Once conidia penetrate the corneal …

Neutrophil and macrophage NADPH oxidase 2 differentially control responses to inflammation and to Aspergillus fumigatus in mice

RA Idol, S Bhattacharya, G Huang, Z Song… - The Journal of …, 2022 - journals.aai.org
Aspergillus fumigatus is an important opportunistic fungal pathogen and causes invasive
pulmonary aspergillosis in conditions with compromised innate antifungal immunity …

The zebrafish as a model host for invasive fungal infections

EE Rosowski, BP Knox, LS Archambault… - Journal of Fungi, 2018 - mdpi.com
The zebrafish has become a widely accepted model host for studies of infectious disease,
including fungal infections. The species is genetically tractable, and the larvae are …

Contributions of spore secondary metabolites to UV-C protection and virulence vary in different Aspergillus fumigatus strains

A Blachowicz, N Raffa, JW Bok, T Choera, B Knox… - MBio, 2020 - Am Soc Microbiol
Fungi are versatile organisms which thrive in hostile environments, including the
International Space Station (ISS). Several isolates of the human pathogen Aspergillus …

Role for IL-1 family cytokines in fungal infections

JS Griffiths, G Camilli, NK Kotowicz, J Ho… - Frontiers in …, 2021 - frontiersin.org
Fungal pathogens kill approximately 1.5 million individuals per year and represent a severe
disease burden worldwide. It is estimated over 150 million people have serious fungal …