Crosstalk between oxidative stress and inflammatory liver injury in the pathogenesis of alcoholic liver disease

YM Yang, YE Cho, S Hwang - International journal of molecular sciences, 2022 - mdpi.com
Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …

Iron, glucose and fat metabolism and obesity: an intertwined relationship

C Hilton, R Sabaratnam, H Drakesmith… - International Journal of …, 2023 - nature.com
A bidirectional relationship exists between adipose tissue metabolism and iron regulation.
Total body fat, fat distribution and exercise influence iron status and components of the iron …

Haemochromatosis

P Brissot, A Pietrangelo, PC Adams… - Nature reviews Disease …, 2018 - nature.com
Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

ACG clinical guideline: hereditary hemochromatosis

KV Kowdley, KE Brown, J Ahn… - Official journal of the …, 2019 - journals.lww.com
Hereditary hemochromatosis (HH) is one of the most common genetic disorders among
persons of northern European descent. There have been recent advances in the diagnosis …

Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin

S Aschemeyer, B Qiao, D Stefanova… - Blood, The Journal …, 2018 - ashpublications.org
Nonclassical ferroportin disease (FD) is a form of hereditary hemochromatosis caused by
mutations in the iron transporter ferroportin (Fpn), resulting in parenchymal iron overload …

Systemic iron homeostasis

T Ganz - Physiological reviews, 2013 - journals.physiology.org
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the
major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron …

[PDF][PDF] Iron overload disorders

CC Hsu, NH Senussi, KY Fertrin… - Hepatology …, 2022 - Wiley Online Library
Iron overload disorders represent a variety of conditions that lead to increased total body
iron stores and resultant end‐organ damage. An elevated ferritin and transferrin‐iron …

Regulation of cellular iron metabolism

J Wang, K Pantopoulos - Biochemical Journal, 2011 - portlandpress.com
Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient
amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is …

Alcoholic liver disease

HK Seitz, R Bataller, H Cortez-Pinto, B Gao… - Nature reviews Disease …, 2018 - nature.com
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide.
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …

Pathogenesis, early diagnosis, and therapeutic management of alcoholic liver disease

LZ Kong, N Chandimali, YH Han, DH Lee… - International journal of …, 2019 - mdpi.com
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to
alcohol overconsumption. It consists of fatty liver/steatosis, alcoholic hepatitis …