Crosstalk between oxidative stress and inflammatory liver injury in the pathogenesis of alcoholic liver disease
Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …
Iron, glucose and fat metabolism and obesity: an intertwined relationship
C Hilton, R Sabaratnam, H Drakesmith… - International Journal of …, 2023 - nature.com
A bidirectional relationship exists between adipose tissue metabolism and iron regulation.
Total body fat, fat distribution and exercise influence iron status and components of the iron …
Total body fat, fat distribution and exercise influence iron status and components of the iron …
Haemochromatosis
P Brissot, A Pietrangelo, PC Adams… - Nature reviews Disease …, 2018 - nature.com
Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …
ACG clinical guideline: hereditary hemochromatosis
KV Kowdley, KE Brown, J Ahn… - Official journal of the …, 2019 - journals.lww.com
Hereditary hemochromatosis (HH) is one of the most common genetic disorders among
persons of northern European descent. There have been recent advances in the diagnosis …
persons of northern European descent. There have been recent advances in the diagnosis …
Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin
S Aschemeyer, B Qiao, D Stefanova… - Blood, The Journal …, 2018 - ashpublications.org
Nonclassical ferroportin disease (FD) is a form of hereditary hemochromatosis caused by
mutations in the iron transporter ferroportin (Fpn), resulting in parenchymal iron overload …
mutations in the iron transporter ferroportin (Fpn), resulting in parenchymal iron overload …
Systemic iron homeostasis
T Ganz - Physiological reviews, 2013 - journals.physiology.org
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the
major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron …
major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron …
[PDF][PDF] Iron overload disorders
Iron overload disorders represent a variety of conditions that lead to increased total body
iron stores and resultant end‐organ damage. An elevated ferritin and transferrin‐iron …
iron stores and resultant end‐organ damage. An elevated ferritin and transferrin‐iron …
Regulation of cellular iron metabolism
J Wang, K Pantopoulos - Biochemical Journal, 2011 - portlandpress.com
Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient
amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is …
amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is …
Alcoholic liver disease
HK Seitz, R Bataller, H Cortez-Pinto, B Gao… - Nature reviews Disease …, 2018 - nature.com
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide.
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …
Pathogenesis, early diagnosis, and therapeutic management of alcoholic liver disease
LZ Kong, N Chandimali, YH Han, DH Lee… - International journal of …, 2019 - mdpi.com
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to
alcohol overconsumption. It consists of fatty liver/steatosis, alcoholic hepatitis …
alcohol overconsumption. It consists of fatty liver/steatosis, alcoholic hepatitis …