In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

We describe here a multiplexed protein quantitation strategy that provides relative and
absolute measurements of proteins in complex mixtures. At the core of this methodology is a …

Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place
across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved …

Ribosome biogenesis is a fundamental process that provides cells with the molecular
factories for cellular protein production. Accordingly, its misregulation lies at the heart of …

Although the U3 small nucleolar RNA (snoRNA), a member of the box C/D class of
snoRNAs, was identified with the spliceosomal small nuclear RNAs (snRNAs) over 30 years …

Ribosome synthesis is a highly complex and coordinated process that occurs not only in the
nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells. Based on the …

In eukaryotic cells, the enclosure of the genetic information in the nucleus allows the spatial
and temporal separation of DNA replication and transcription from cytoplasmic protein …