Platelets produce platelet growth factors such as PDGF, IGF-1, EGF-, HGF, TGFβ, bFGF, and
VEGF, which are crucial in regulating all stages of the wound healing process. The source of …

Background: Platelet-rich plasma (PRP) is a blood-derived preparation whose use has
grown exponentially in orthopaedic practice. However, there remains an unclear …

Importance Approximately 3.4% of adults have ankle (tibiotalar) osteoarthritis and, among
younger patients, ankle osteoarthritis is more common than knee and hip osteoarthritis. Few …

Background The absence of a single, identifiable traumatic cause has been traditionally
used as a definition for a causative factor of overuse injury. Excessive loading, insufficient …

Tendon injuries are common and present a clinical challenge to orthopedic surgery mainly
because these injuries often respond poorly to treatment and require prolonged …

Tendinopathy is a multifactorial spectrum of tendon disorders that affects different
anatomical sites and is characterized by activity-related tendon pain. These disorders are …

Objective To compare the effectiveness of progressive tendon-loading exercises (PTLE) with
eccentric exercise therapy (EET) in patients with patellar tendinopathy (PT). Methods In a …

The clinical application of platelet-rich plasma (PRP) and other regenerative therapies in
sports, spine, and musculoskeletal medicine has soared in the last decade. Over this period …

Background: There has been a surge in high-level studies investigating platelet-rich plasma
(PRP) for tendon and ligament injuries. A number of meta-analyses have been published …

The Orthopaedic Section of the American Physical Therapy Association (APTA) has an
ongoing effort to create evidence-based practice guidelines for orthopaedic physical therapy …