Cellular senescence is an irreversible arrest of cell growth. Biochemical and morphological
changes occur during cellular senescence, including the formation of a unique cellular …

Heterochromatin maintenance is crucial for the clonal inheritance of cell identity, to ensure
the proper segregation of chromosomes and the regulation of gene expression. Although it …

The organization of chromatin into higher-order structures influences chromosome function
and epigenetic gene regulation. Higher-order chromatin has been proposed to be nucleated …

Abstract Heterochromatin protein 1 (HP1) is localized at heterochromatin sites where it
mediates gene silencing,. The chromo domain of HP1 is necessary for both targeting and …

Distinct modifications of histone amino termini, such as acetylation, phosphorylation and
methylation, have been proposed to underlie a chromatin-based regulatory mechanism, that …

The chromodomain of the HP1 family of proteins recognizes histone tails with specifically
methylated lysines. Here, we present structural, energetic, and mutational analyses of the …

Specific modifications to histones are essential epigenetic markers—heritable changes in
gene expression that do not affect the DNA sequence. Methylation of lysine 9 in histone H3 …

Chromatin is a highly dynamic structure that imparts structural organization to the genome
and regulates the gene expression underneath. The decade long research in deciphering …

We have identified a family of 'Agenet'domains that are plant-specific homologs of Tudor
domains. This finding has been extended, using a combination of sequence-and structure …

1. INTRODUCTION In eukaryotic cells, inheritable information is stored in a nucleoprotein
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On …