Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …

Airway remodeling is generally quite broadly defined as any change in composition,
distribution, thickness, mass or volume and/or number of structural components observed in …

The pathogenesis of idiopathic pulmonary fibrosis (IPF), an intractable interstitial lung
disease, is unclear. Recessive mutations in some genes implicated in Hermansky-Pudlak …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease where invasive
pulmonary myofibroblasts secrete collagen and destroy lung integrity. Here, we show that …

The objective of this study is to examine IL-11-induced mechanisms of inflammatory cell
migration to the central nervous system (CNS). We report that IL-11 is produced at highest …

Cytokines and chemokines are secreted proteins involved in numerous aspects of cell
growth, differentiation, and activation. A prominent feature of these molecules is their effect …

Airway remodeling encompasses the structural alterations in asthmatic compared with
normal airways. Airway remodeling in asthmatic patients involves a wide array of …

Interleukin (IL)-11 is upregulated in a wide variety of fibro-inflammatory diseases such as
systemic sclerosis, rheumatoid arthritis, pulmonary fibrosis, inflammatory bowel disease …

Background: IL-17 is a cytokine that has been reported to be produced by T lymphocytes. In
vitro, IL-17 activates fibro-blasts and macrophages for the secretion of GM-CSF, TNF-α, IL …

Human pulmonary fibrosis is characterized by alveolar epithelial cell injury, areas of type II
cell hyperplasia, accumulation of fibroblasts and myofibroblasts, and the deposition of …