Updating the striatal–pallidal wiring diagram

LZ Fang, MC Creed - Nature neuroscience, 2024 - nature.com
The striatal and pallidal complexes are basal ganglia structures that orchestrate learning
and execution of flexible behavior. Models of how the basal ganglia subserve these …

Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens

AK Zinsmaier, Y Dong, YH Huang - Molecular psychiatry, 2022 - nature.com
Cocaine craving, seeking, and relapse are mediated, in part, by cocaine-induced adaptive
changes in the brain reward circuits. The nucleus accumbens (NAc) integrates and …

Ventral pallidal regulation of motivated behaviors and reinforcement

C Soares-Cunha, JA Heinsbroek - Frontiers in Neural Circuits, 2023 - frontiersin.org
The interconnected nuclei of the ventral basal ganglia have long been identified as key
regulators of motivated behavior, and dysfunction of this circuit is strongly implicated in …

A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state

Z Liu, Q Le, Y Lv, X Chen, J Cui, Y Zhou, D Cheng… - Cell research, 2022 - nature.com
Dopamine (DA) level in the nucleus accumbens (NAc) is critical for reward and aversion
encoding. DA released from the ventral mesencephalon (VM) DAergic neurons increases …

Dopamine receptors: is it possible to become a therapeutic target for depression?

F Zhao, Z Cheng, J Piao, R Cui, B Li - Frontiers in Pharmacology, 2022 - frontiersin.org
Dopamine and its receptors are currently recognized targets for the treatment of several
neuropsychiatric disorders, including Parkinson's disease, schizophrenia, some drug use …

How changes in dopamine D2 receptor levels alter striatal circuit function and motivation

EH Simpson, EF Gallo, PD Balsam, JA Javitch… - Molecular …, 2022 - nature.com
It was first posited, more than five decades ago, that the etiology of schizophrenia involves
overstimulation of dopamine receptors. Since then, advanced clinical research methods …

Ventral pallidum cellular and pathway specificity in drug seeking

YM Kupchik, AA Prasad - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
The ventral pallidum (VP) is central to the reinforcing effects across a variety of drugs and
relapse to drug seeking. Emerging studies from animal models of reinstatement reveal a …

A non-canonical striatopallidal Go pathway that supports motor control

MA Labouesse, A Torres-Herraez, MO Chohan… - Nature …, 2023 - nature.com
In the classical model of the basal ganglia, direct pathway striatal projection neurons
(dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to …

Cell-type-specific adaptions in striatal medium-sized spiny neurons and their roles in behavioral responses to drugs of abuse

MC Allichon, V Ortiz, P Pousinha… - Frontiers in synaptic …, 2021 - frontiersin.org
Drug addiction is defined as a compulsive pattern of drug-seeking-and taking-behavior, with
recurrent episodes of abstinence and relapse, and a loss of control despite negative …

The nucleus accumbens shell: a neural hub at the interface of homeostatic and hedonic feeding

AM Marinescu, MA Labouesse - Frontiers in Neuroscience, 2024 - frontiersin.org
Feeding behavior is a complex physiological process regulated by the interplay between
homeostatic and hedonic feeding circuits. Among the neural structures involved, the nucleus …