Updating the striatal–pallidal wiring diagram
The striatal and pallidal complexes are basal ganglia structures that orchestrate learning
and execution of flexible behavior. Models of how the basal ganglia subserve these …
and execution of flexible behavior. Models of how the basal ganglia subserve these …
Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens
AK Zinsmaier, Y Dong, YH Huang - Molecular psychiatry, 2022 - nature.com
Cocaine craving, seeking, and relapse are mediated, in part, by cocaine-induced adaptive
changes in the brain reward circuits. The nucleus accumbens (NAc) integrates and …
changes in the brain reward circuits. The nucleus accumbens (NAc) integrates and …
Ventral pallidal regulation of motivated behaviors and reinforcement
C Soares-Cunha, JA Heinsbroek - Frontiers in Neural Circuits, 2023 - frontiersin.org
The interconnected nuclei of the ventral basal ganglia have long been identified as key
regulators of motivated behavior, and dysfunction of this circuit is strongly implicated in …
regulators of motivated behavior, and dysfunction of this circuit is strongly implicated in …
A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state
Z Liu, Q Le, Y Lv, X Chen, J Cui, Y Zhou, D Cheng… - Cell research, 2022 - nature.com
Dopamine (DA) level in the nucleus accumbens (NAc) is critical for reward and aversion
encoding. DA released from the ventral mesencephalon (VM) DAergic neurons increases …
encoding. DA released from the ventral mesencephalon (VM) DAergic neurons increases …
Dopamine receptors: is it possible to become a therapeutic target for depression?
F Zhao, Z Cheng, J Piao, R Cui, B Li - Frontiers in Pharmacology, 2022 - frontiersin.org
Dopamine and its receptors are currently recognized targets for the treatment of several
neuropsychiatric disorders, including Parkinson's disease, schizophrenia, some drug use …
neuropsychiatric disorders, including Parkinson's disease, schizophrenia, some drug use …
How changes in dopamine D2 receptor levels alter striatal circuit function and motivation
It was first posited, more than five decades ago, that the etiology of schizophrenia involves
overstimulation of dopamine receptors. Since then, advanced clinical research methods …
overstimulation of dopamine receptors. Since then, advanced clinical research methods …
Ventral pallidum cellular and pathway specificity in drug seeking
YM Kupchik, AA Prasad - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
The ventral pallidum (VP) is central to the reinforcing effects across a variety of drugs and
relapse to drug seeking. Emerging studies from animal models of reinstatement reveal a …
relapse to drug seeking. Emerging studies from animal models of reinstatement reveal a …
A non-canonical striatopallidal Go pathway that supports motor control
In the classical model of the basal ganglia, direct pathway striatal projection neurons
(dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to …
(dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to …
Cell-type-specific adaptions in striatal medium-sized spiny neurons and their roles in behavioral responses to drugs of abuse
MC Allichon, V Ortiz, P Pousinha… - Frontiers in synaptic …, 2021 - frontiersin.org
Drug addiction is defined as a compulsive pattern of drug-seeking-and taking-behavior, with
recurrent episodes of abstinence and relapse, and a loss of control despite negative …
recurrent episodes of abstinence and relapse, and a loss of control despite negative …
The nucleus accumbens shell: a neural hub at the interface of homeostatic and hedonic feeding
AM Marinescu, MA Labouesse - Frontiers in Neuroscience, 2024 - frontiersin.org
Feeding behavior is a complex physiological process regulated by the interplay between
homeostatic and hedonic feeding circuits. Among the neural structures involved, the nucleus …
homeostatic and hedonic feeding circuits. Among the neural structures involved, the nucleus …