Prostate cancer is the second-leading cause of cancer-related mortality in men in Western
societies. Androgen receptor (AR) signaling is a critical survival pathway for prostate cancer …

Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

The level of copy number alteration (CNA), termed CNA burden, in the tumor genome is
associated with recurrence of primary prostate cancer. Whether CNA burden is associated …

We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the
context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples …

Overexpression of amplified genes is often associated with the acquisition of resistance to
cancer therapeutic agents in vitro. We have identified a similar molecular mechanism in vivo …

Prostate cancer afflicts one man in nine over the age of 65 and represents the most
frequently diagnosed cancer in American men (Coffey 1993). Early detection through serum …

Many studies have shown that primary prostate cancers are multifocal,, and are composed
of multiple genetically distinct cancer cell clones,,. Whether or not multiclonal primary …

Cancer is one of the leading causes of death, and despite increased research in recent
years, control of advanced-stage disease and optimal therapeutic responses remain elusive …

A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on
chromosome 8q24 as significantly associated with susceptibility to prostate cancer …

Prostate cancer, the majority of which is adenocarcinoma, is the most common epithelial
cancer affecting a majority of elderly men in Western nations. Its manifestation, however …