PARP inhibitors: clinical relevance, mechanisms of action and tumor resistance
The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular
processes, including the regulation of transcription, apoptosis and the DNA damage …
processes, including the regulation of transcription, apoptosis and the DNA damage …
[HTML][HTML] Advances in CRISPR therapeutics
The clustered regularly interspaced short palindromic repeats (CRISPR) renaissance was
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …
CRISPR-based genome editing through the lens of DNA repair
Genome editing technologies operate by inducing site-specific DNA perturbations that are
resolved by cellular DNA repair pathways. Products of genome editors include DNA breaks …
resolved by cellular DNA repair pathways. Products of genome editors include DNA breaks …
Predictable and precise template-free CRISPR editing of pathogenic variants
Following Cas9 cleavage, DNA repair without a donor template is generally considered
stochastic, heterogeneous and impractical beyond gene disruption. Here, we show that …
stochastic, heterogeneous and impractical beyond gene disruption. Here, we show that …
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C: G-to-T: A base editors with higher efficiency and product purity
We recently developed base editing, the programmable conversion of target C: G base pairs
to T: A without inducing double-stranded DNA breaks (DSBs) or requiring homology …
to T: A without inducing double-stranded DNA breaks (DSBs) or requiring homology …
Elucidating the mechanisms of Temozolomide resistance in gliomas and the strategies to overcome the resistance.
Temozolomide (TMZ) is a first-choice alkylating agent inducted as a gold standard therapy
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …
Targeting DNA repair in cancer: beyond PARP inhibitors
JS Brown, B O'Carrigan, SP Jackson, TA Yap - Cancer discovery, 2017 - AACR
Germline aberrations in critical DNA-repair and DNA damage–response (DDR) genes
cause cancer predisposition, whereas various tumors harbor somatic mutations causing …
cause cancer predisposition, whereas various tumors harbor somatic mutations causing …
Carcinogens and DNA damage
JL Barnes, M Zubair, K John, MC Poirier… - Biochemical Society …, 2018 - portlandpress.com
Humans are variously and continuously exposed to a wide range of different DNA-damaging
agents, some of which are classed as carcinogens. DNA damage can arise from exposure to …
agents, some of which are classed as carcinogens. DNA damage can arise from exposure to …
CRISPR/Cas9-based precise excision of SlHyPRP1 domain (s) to obtain salt stress-tolerant tomato
Key message CRISPR/Cas9-based multiplexed editing of SlHyPRP1 resulted in precise
deletions of its functional motif (s), thereby resulting in salt stress-tolerant events in cultivated …
deletions of its functional motif (s), thereby resulting in salt stress-tolerant events in cultivated …
Non-histone protein methylation as a regulator of cellular signalling and function
Abstract Methylation of Lys and Arg residues on non-histone proteins has emerged as a
prevalent post-translational modification and as an important regulator of cellular signal …
prevalent post-translational modification and as an important regulator of cellular signal …