Pneumococcal polysaccharide vaccines (PPVs) and conjugate vaccines (PCVs), of which
PPV23 and PCV13 are the current front runners, have had a significant, beneficial impact on …

Polysaccharides are abundant natural polymers, which in nature are at times covalently
modified with peptides and proteins. Polysaccharide–protein or polysaccharide–peptide …

The study of proteins and protein complexes using chemical cross-linking followed by the
MS identification of the cross-linked peptides has found increasingly widespread use in …

The development of vaccines against polysaccharide-encapsulated pathogens (eg
Haemophilus influenzae type b, pneumococci, meningococci) is challenging because …

During the last decade there has been a growing interest in glycoimmunology, a relatively
new research field dealing with the specific interactions of carbohydrates with the immune …

Despite the efforts to expand the availability of conjugate vaccines, pneumococcal diseases
still pose an enormous burden worldwide. Therefore, several proteins have been …

Introduction: Serotype replacement–a consequence of polysaccharide vaccine use–will
continue to drive the inclusion of new serotypes on conjugate vaccines, increasing …

With an increase in antibiotic-resistant strains, the nosocomial pathogen Acinetobacter
baumannii has become a serious threat to global health. Glycoconjugate vaccines …

Pseudaminic acid (Pse) has been known for participating in crucial bacterial virulence and
thus is an attractive target in the development of glycoconjugate vaccine. Particularly, this …

Several studies have searched for new antigens to produce pneumococcal vaccines that are
more effective and could provide broader coverage, given the great number of serotypes …