Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology

M Zhu, H Sun, L Cao, Z Wu, B Leng, J Bian - Journal of Molecular …, 2022 - Springer
Abstract Na+/K+-ATPase (NKA) is a large transmembrane protein expressed in all cells. It is
well studied for its ion exchanging function, which is indispensable for the maintenance of …

Hypoxic stress-dependent regulation of Na, K-ATPase in ischemic heart disease

E Baloglu - International Journal of Molecular Sciences, 2023 - mdpi.com
In cardiomyocytes, regular activity of the Na, K-ATPase (NKA) and its Na/K pump activity is
essential for maintaining ion gradients, excitability, propagation of action potentials, electro …

Na, K-ATPase acts as a beta-amyloid receptor triggering src kinase activation

IY Petrushanko, AM Tverskoi, EP Barykin… - Cells, 2022 - mdpi.com
Beta-amyloid (Aβ) has a dual role, both as an important factor in the pathology of
Alzheimer's disease and as a regulator in brain physiology. The inhibitory effect of Aβ42 …

The Na/K-ATPase α1 and c-Src form signaling complex under native condition: A crosslinking approach

Y Nie, F Bai, MA Chaudhry, R Pratt, JI Shapiro, J Liu - Scientific Reports, 2020 - nature.com
The protein-protein interactions amongst the Na/K-ATPase α1 subunit, c-Src, and caveolin-1
(cav-1) are essential for the Na/K-ATPase signaling functions. However, there are …

Oral digoxin effects on exercise performance, K+ regulation and skeletal muscle Na+,K+‐ATPase in healthy humans

S Sostaric, AC Petersen, CA Goodman… - The Journal of …, 2022 - Wiley Online Library
We investigated whether digoxin lowered muscle Na+, K+‐ATPase (NKA), impaired muscle
performance and exacerbated exercise K+ disturbances. Ten healthy adults ingested …

Glutathione-related substances maintain cardiomyocyte contractile function in hypoxic conditions

YM Poluektov, IY Petrushanko, NA Undrovinas… - Scientific Reports, 2019 - nature.com
Severe hypoxia leads to decline in cardiac contractility and induces arrhythmic events in part
due to oxidative damage to cardiomyocyte proteins including ion transporters. This results in …

[HTML][HTML] Fermencin B2: A promising heat-stable cationic peptide for targeted inhibition of Staphylococcus aureus

J Xu, X Fan, Y Hu, M Liu, L Du, Z Wu, M Tu, N Ling… - LWT, 2024 - Elsevier
In this study, a novel strain of L. fermentum JF9 with bacteriocin production capacity was
firstly isolated from Chinese fermented vinegar Pei, and the significant antibacterial potential …

[HTML][HTML] Redox regulation of glutathione peroxidase by thioredoxin in longan fruit in relation to senescence and quality deterioration

F Wu, G Jiang, H Yan, L Xiao, H Liang, D Zhang… - Food Chemistry, 2021 - Elsevier
Thioredoxins (Trxs) are important redox regulators in organisms. However, their involvement
in fruit senescence and quality deterioration remains unclear. In this study, one Trx (DlTrx1) …

The redox-sensitive Na/K-ATPase signaling in uremic cardiomyopathy

J Liu, Y Nie, M Chaudhry, F Bai, J Chuang… - International Journal of …, 2020 - mdpi.com
In recent years, Na/K-ATPase signaling has been implicated in different physiological and
pathophysiological conditions, including cardiac hypertrophy and uremic cardiomyopathy …

Metabolic syndrome and salt-sensitive hypertension in polygenic obese TALLYHO/JngJ mice: role of Na/K-ATPase signaling

Y Yan, J Wang, MA Chaudhry, Y Nie, S Sun… - International journal of …, 2019 - mdpi.com
We have demonstrated that Na/K-ATPase acts as a receptor for reactive oxygen species
(ROS), regulating renal Na+ handling and blood pressure. TALLYHO/JngJ (TH) mice are …