Epstein–Barr virus latent genes

MS Kang, E Kieff - Experimental & molecular medicine, 2015 - nature.com
Abstract Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …

The latent membrane protein 1 (LMP1)

A Kieser, KR Sterz - Epstein Barr Virus Volume 2: One Herpes Virus: Many …, 2015 - Springer
Almost exactly twenty years after the discovery of Epstein-Barr virus (EBV), the latent
membrane protein 1 (LMP1) entered the EBV stage, and soon thereafter, it was recognized …

Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen

ME Ballestas, PA Chatis, KM Kaye - Science, 1999 - science.org
Primary effusion lymphoma (PEL) cells harbor Kaposi's sarcoma–associated herpesvirus
(KSHV) episomes and express a KSHV-encoded latency-associated nuclear antigen …

[HTML][HTML] The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

G Mosialos, M Birkenbacht, R Yalamanchill… - Cell, 1995 - cell.com
The cytoplasmic C-terminus of Epstein-Barr virus (EBV) latent infection membrane protein 1
(LMP1) is essential for B lymphocyte growth transformation and is now shown to interact with …

[HTML][HTML] Latent membrane protein 1 of Epstein–Barr virus interacts with JAK3 and activates STAT proteins

O Gires, F Kohlhuber, E Kilger, M Baumann… - The EMBO …, 1999 - embopress.org
Abstract Latent membrane protein 1 (LMP1) acts like a permanently activated receptor of the
tumor necrosis factor (TNF)‐receptor superfamily and is absolutely required for B cell …

Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-κB activation

O Devergne, E Hatzivassiliou, KM Izumi… - … and cellular biology, 1996 - Am Soc Microbiol
Abstract The Epstein-Barr virus (EBV) transforming protein LMP1 appears to be a
constitutively activated tumor necrosis factor receptor (TNFR) on the basis of an intrinsic …

Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways

JE Cameron, Q Yin, C Fewell, M Lacey… - Journal of …, 2008 - Am Soc Microbiol
ABSTRACT The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a
functional homologue of the tumor necrosis factor receptor family and contributes …

The Epstein–Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B …

KM Izumi, ED Kieff - … of the National Academy of Sciences, 1997 - National Acad Sciences
The Epstein–Barr virus latent membrane protein 1 (LMP1) is essential for the transformation
of B lymphocytes into lymphoblastoid cell lines. Previous data are consistent with a model …

Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus-encoded latent membrane protein 1 coregulates interleukin-6 and interleukin-8 …

AG Eliopoulos, NJ Gallagher, SMS Blake… - Journal of Biological …, 1999 - ASBMB
The Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) is a pleiotropic protein
the activities of which include effects on gene expression and cell transformation, growth …

Cancers associated with human gammaherpesviruses

KW Wen, L Wang, JR Menke, B Damania - The FEBS journal, 2022 - Wiley Online Library
Epstein–Barr virus (EBV; human herpesvirus 4; HHV‐4) and Kaposi sarcoma‐associated
herpesvirus (KSHV; human herpesvirus 8; HHV‐8) are human gammaherpesviruses that …