DNA transposons offer an efficient nonviral method of permanently modifying the genomes
of mammalian cells. The piggyBac transposon system has proven effective in genomic …

Over a decade ago, a landmark study that reported derivation of induced Pluripotent Stem
Cells (iPSCs) by reprogramming fibroblasts has transformed stem cell research attracting …

Chimeric antigen receptor‐T (CAR‐T) cell immunotherapy has shown impressive clinical
outcomes for hematologic malignancies. However, its broader applications are challenged …

DNA transposons are defined segments of DNA that are able to move from one genomic
location to another. Movement is facilitated by one or more proteins, called the transposase …

The next generation of therapeutic products to be approved for the clinic is anticipated to be
cell therapies, termed “living drugs” for their capacity to dynamically and temporally respond …

Subsequent malignancies are well-documented complications in long-term follow-up of
cancer patients. Recently, genetically modified immune effector (IE) cells have shown …

Stargardt macular dystrophy (Stargardt disease; STGD1; OMIM 248200) is the most
prevalent inherited macular dystrophy. STGD1 is an autosomal recessive disorder caused …

Yarrowia lipolytica is a non‐conventional yeast of interest to the biotechnology industry.
However, the physiology, metabolism, and genetic regulation of Y. lipolytica diverge …

The non‐conventional oleaginous yeast Yarrowia lipolytica is able to utilize both hydrophilic
and hydrophobic carbon sources as substrates and convert them into value‐added …

In recent years, mammalian cells have become the primary host cells for the production of
recombinant therapeutic proteins (RTPs). Despite that the expression of RTPs in mammalian …