Background/Objective: Skin fibrosis is the result of aberrant processes leading to abnormal
deposition of extracellular matrix (ECM) in the dermis. In healthy skin, keratinocytes …

Tissue repair is a very complex event and involves a continuously orchestrated sequence of
signals and responses from platelets, fibroblasts, epithelial, endothelial and immune cells …

Rationale: With over seven million infections and $25 billion treatment cost, chronic ischemic
wounds are one of the most serious complications in the United States. The controlled …

Postoperative abdominal adhesions are a common problem after surgery and can produce
serious complications. Current antiadhesive strategies focus mostly on physical barriers and …

Excessive release of neutrophil extracellular traps (NETs) has been implicated in several
organ fibrosis, including pulmonary fibrosis. NETs constitute a phenomenon in which …

Background Renal interstitial fibrosis (RIF) is one of the main features of diabetic
nephropathy (DN), but the molecular mechanisms mediating RIF in DN has yet been fully …

The S100 family proteins possess a variety of intracellular and extracellular functions. They
interact with multiple receptors and signal transducers to regulate pathways that govern …

Unlike adult cardiomyocytes, neonatal cardiomyocytes can readily proliferate that
contributes to a transient regenerative potential after myocardial injury in mice. We have …

Inflammation is a key phase in the cutaneous wound repair process. The activation of
inflammatory cells is critical for preventing infection in contaminated wounds and results in …

Elevated neutrophil count is associated with higher risk of major adverse cardiac events
including myocardial infarction and early development of heart failure. Neutrophils …