Abstract Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a
developmental encephalopathy caused by pathogenic variants in the gene CDKL5. This …

Autism spectrum disorder (ASD) is defined by impaired social interaction and
communication accompanied by stereotyped behaviors and restricted interests. Although …

The cellular mechanisms of autism spectrum disorder (ASD) are poorly understood.
Cumulative evidence suggests that abnormal synapse function underlies many features of …

Neuroplasticity refers to the ability of brain circuits to reorganize and change the properties
of the network, resulting in alterations in brain function and behavior. It is traditionally …

CDKL5 deficiency disorder (CDD) is an early onset, neurodevelopmental syndrome
associated with pathogenic variants in the X-linked gene encoding cyclin-dependent kinase …

Mutations in cyclin-dependent kinase-like 5 (CDKL5) cause early-onset epileptic
encephalopathy, a neurodevelopmental disorder with similarities to Rett Syndrome. Here we …

Early-onset epileptic encephalopathies are severe disorders often associated with specific
genetic mutations. In this context, the CDKL5 deficiency disorder (CDD) is a …

Background CDKL5 (cyclin-dependent kinase-like 5) is mutated in many severe
neurodevelopmental disorders, including atypical wRett syndrome. CDKL5 was shown to …

The mechanistic target of rapamycin (mTOR) is an important signaling hub that integrates
environmental information regarding energy availability and stimulates anabolic molecular …

Mutations in the Cyclin-dependent kinase-like 5 (CDKL5) gene cause severe
neurodevelopmental disorders accompanied by intractable epilepsies, ie West syndrome or …