Chimeric antigen receptor (CAR) gene-engineered T cell therapy holds the potential to
make a meaningful difference in the lives of patients with terminal cancers. For decades …

The inhibitory immune receptor programmed cell death-1 (PD-1) is intricately regulated. In T
cells, PD-1 is expressed in response to most immune challenges, but it is rapidly …

Although CD4+ T cell" help" is crucial to sustain antiviral immunity, the mechanisms by
which CD4+ T cells regulate CD8+ T cell differentiation during chronic infection remain …

Certain bacterial colonists induce a highly specific T cell response. A hallmark of this
encounter is that adaptive immunity develops preemptively, in the absence of an infection …

Abstract Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N
domain, which mediates pyroptosis by forming pores in the plasma membrane. Here we …

Bidirectional signalling between the tumour and stroma shapes tumour aggressiveness and
metastasis. ATF4 is a major effector of the Integrated Stress Response, a homeostatic …

Antigen cross-presentation, wherein dendritic cells (DCs) present exogenous antigen on
major histocompatibility class I (MHC-I) molecules, is considered the primary mechanism by …

The recent success of immunotherapies has highlighted the power of leveraging the
immune system in the fight against cancer. In order for most immune‐based therapies to …

Cancer vaccines must activate multiple immune cell types to be effective against aggressive
tumours. Here we report the impact of the structural presentation of two antigenic peptides …

Alterations in gut microbiota impact the pathophysiology of several diseases, including
cancer. Radiotherapy (RT), an established curative and palliative cancer treatment, exerts …