Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

Of all cells implicated in the pathology of rheumatoid arthritis (RA), neutrophils possess the
greatest cytotoxic potential, owing to their ability to release degradative enzymes and …

Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting synovial joints.
Neutrophils are believed to play an important role in both the initiation and progression of …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first described as a
growth factor that induces the differentiation and proliferation of myeloid progenitors in the …

In inflammatory conditions such as RA, the neutrophil has tended to be dismissed as a short-
lived, terminally differentiated, irrelevant bystander cell. However, this is clearly not the case …

Myeloid cells comprise the majority of immune cells in tumors, contributing to tumor growth
and therapeutic resistance. Incomplete understanding of myeloid cells response to tumor …

Rheumatoid arthritis (RA), a common autoimmune disease, is characterized by a highly
coordinated inflammatory response that involves innate and adaptive immunity. One of the …

Granulocytes, the most abundant types of leukocytes, are the first line of defense against
pathogen invasion. However, the plasticity and diversity of granulocytes have been …

Neutrophils (also called polymorphonuclear leukocytes, PMNs) are the most abundant white
blood cells in humans and play a central role in innate host defense. Another distinguishing …

Cellular growth and proliferation depend upon the acquisition and synthesis of specific
metabolites. These metabolites fuel the bioenergy, biosynthesis, and redox potential …