This review examines how the sympathetic nervous system plays a major role in the
regulation of cardiovascular function over multiple time scales. This is achieved through …

Left ventricular hypertrophy (LVH) is the major risk factor associated with myocardial failure.
An explanation for why a presumptive adaptation such as LVH would prove pathological has …

Primary aldosteronism (PA), a common cause of high blood pressure (BP), induces left
ventricular (LV) hypertrophy and an excess rate of cardiovascular events. Whether its …

A method has been developed for culturing cardiac myocytes in a collagen matrix to
produce a coherently contracting 3‐dimensional model heart tissue that allows direct …

The definition of whether and how advancing age affects cardiovascular structure and
function is a formidable research endeavor because other factors that covary with age, ie …

▪ Abstract External load plays a critical role in determining muscle mass and its phenotype in
cardiac myocytes. Cardiac myocytes have the ability to sense mechanical stretch and …

Although animal models of hypertension have clearly shown that high blood pressure is
associated with and is probably caused by an increase in sympathetic cardiovascular …

Potassium channels play important roles in vital cellular signaling processes in both
excitable and nonexcitable cells. Over 50 human genes encoding various K+ channels have …

Background—The role of androgens in producing cardiac hypertrophy by direct action on
cardiac myocytes is uncertain. Accordingly, we tested the hypothesis that cardiac myocytes …

Cardiac remodeling, which is characterized by mechanical and electrical remodeling, is a
significant pathophysiological process involved in almost all forms of heart diseases …