Introduction Toxicity data are unavailable for many thousands of chemicals in commerce
and the environment. Therefore, risk assessors need to rapidly screen these chemicals for …

Nowadays, conducting discriminative dissolution experiments employing physiologically
based pharmacokinetic modeling (PBPK) or physiologically based biopharmaceutical …

With an increasing need to incorporate new approach methodologies (NAMs) in chemical
risk assessment and the concomitant need to phase out animal testing, the interpretation of …

Abstract Systems biology aims to understand living organisms through mathematically
modeling their behaviors at different organizational levels, ranging from molecules to …

Physiologically based pharmacokinetic (PBPK) models are a means of making important
linkages between exposure assessment and in vitro toxicity. A key constraint on rapid …

As a key step in next-generation risk assessment (NGRA), in vitro to in vivo extrapolation
(IVIVE) aims to mobilize a mechanism-based understanding of toxicology to translate …

Traditional animal testing for toxicity is expensive, time consuming, ethically questioned,
sometimes inaccurate because of the necessity to extrapolate from animal to human, and in …

Purpose The data acquisition of drug metabolism analysis requires a lot of time and animal
resources. However, there are often many deviations in the results of pharmacokinetic …

The term toxicokinetics refers to the study of absorption, distribution, metabolism
(biotransformation), and excretion (ADME) of toxicants in living organisms in relation to time …

This thesis investigates the pharmacokinetics of orally administered small interfering RNA
(siRNA) for the treatment of Inflammatory Bowel Disease (IBD). This study involves the …