5-fluorouracil (5-FU) is among the mostly administrated chemotherapeutic agents for a wide
variety of neoplasms. Non-coding RNAs have a central impact on the determination of the …

MicroRNAs (miRNAs) are small, single-stranded, noncoding RNAs that can post-
transcriptionally regulate the expression of various oncogenes and tumor suppressor genes …

Chemotherapy is one of the basic treatments for cancers; however, drug resistance is mainly
responsible for the failure of clinical treatment. The mechanism of drug resistance is …

Epigenetic regulation by microRNAs (miRs) demonstrated a promising therapeutic potential
of these molecules to regulate genetic activity in different cancers, including colorectal …

Non-coding RNAs (ncRNAs) have been implicated in most cellular functions. The disruption
of their function through somatic mutations, genomic imprinting, transcriptional and post …

Innate and acquired chemoresistance exhibited by most tumours exposed to conventional
chemotherapeutic agents account for the majority of relapse cases in cancer patients. Such …

Long intergenic non-coding RNA 152 (LINC00152) is a recently identified tumor-promoting
long non-coding RNA. However, the biological functions of LINC00152 in colorectal cancer …

MicroRNAs (miRNAs) play crucial roles in human disease and can be targeted by small
molecule (SM) drugs according to numerous studies, which shows that identifying SM …

Chemo-resistance, which is the main obstacle in cancer therapy, is caused by the onset of
drug-resistant cells in the heterogeneous cell population in cancer tissues. MicroRNAs …

Background Colorectal cancer (CRC) is one of the most common gastrointestinal
malignancies with a significant mortality rate. Despite the great advances in cancer …