[HTML][HTML] A decade of advances in transposon-insertion sequencing
It has been 10 years since the introduction of modern transposon-insertion sequencing (TIS)
methods, which combine genome-wide transposon mutagenesis with high-throughput …
methods, which combine genome-wide transposon mutagenesis with high-throughput …
[HTML][HTML] Impact of historic migrations and evolutionary processes on human immunity
J Domínguez-Andrés, MG Netea - Trends in Immunology, 2019 - cell.com
The evolution of mankind has constantly been influenced by the pathogens encountered.
The various populations of modern humans that ventured out of Africa adapted to different …
The various populations of modern humans that ventured out of Africa adapted to different …
[图书][B] Fields virology: Emerging viruses
Now in four convenient volumes, Field's Virology remains the most authoritative reference in
this fast-changing field, providing definitive coverage of virology, including virus biology as …
this fast-changing field, providing definitive coverage of virology, including virus biology as …
[HTML][HTML] Staphylococcus aureus infection dynamics
EJG Pollitt, PT Szkuta, N Burns, SJ Foster - PLoS pathogens, 2018 - journals.plos.org
Staphylococcus aureus is a human commensal that can also cause systemic infections. This
transition requires evasion of the immune response and the ability to exploit different niches …
transition requires evasion of the immune response and the ability to exploit different niches …
[HTML][HTML] Probabilistic invasion underlies natural gut microbiome stability
Species compositions of gut microbiomes impact host health [1–3], but the processes
determining these compositions are largely unknown. An unexplained observation is that …
determining these compositions are largely unknown. An unexplained observation is that …
Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis
Infection with Mycobacterium tuberculosis causes a spectrum of outcomes; the majority of
individuals contain but do not eliminate the infection, while a small subset present with …
individuals contain but do not eliminate the infection, while a small subset present with …
[HTML][HTML] Exploration of bacterial bottlenecks and Streptococcus pneumoniae pathogenesis by CRISPRi-Seq
Streptococcus pneumoniae is an opportunistic human pathogen that causes invasive
diseases, including pneumonia, with greater health risks upon influenza A virus (IAV) co …
diseases, including pneumonia, with greater health risks upon influenza A virus (IAV) co …
[HTML][HTML] Bottleneck size and selection level reproducibly impact evolution of antibiotic resistance
N Mahrt, A Tietze, S Künzel, S Franzenburg… - Nature Ecology & …, 2021 - nature.com
During antibiotic treatment, the evolution of bacterial pathogens is fundamentally affected by
bottlenecks and varying selection levels imposed by the drugs. Bottlenecks—that is …
bottlenecks and varying selection levels imposed by the drugs. Bottlenecks—that is …
[HTML][HTML] Stochastic assembly produces heterogeneous communities in the Caenorhabditis elegans intestine
Host-associated bacterial communities vary extensively between individuals, but it can be
very difficult to determine the sources of this heterogeneity. Here, we demonstrate that …
very difficult to determine the sources of this heterogeneity. Here, we demonstrate that …
Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections
During severe infections, Staphylococcus aureus moves from its colonising sites to blood
and tissues and is exposed to new selective pressures, thus, potentially driving adaptive …
and tissues and is exposed to new selective pressures, thus, potentially driving adaptive …