Neurodegenerative diseases are chronic, progressive disorders that occur in the central
nervous system (CNS). They are characterized by the loss of neuronal structure and function …

In recent years, scientists studying the molecular mechanisms of inflammation have
discovered an amazing phenomenon–the inflammasome–a component of the innate …

Highlights•New world Leishmania species LV guyanensis and LV braziliensis harbor LRV1
virus that can exacerbate the disease.•LLRV1 can exit from Leishmania enveloped within …

Leishmaniasis is a global health problem that affects more than 2 billion people worldwide.
Recent advances in research have demonstrated critical roles for cytoplasmic sensors and …

Nucleotide-binding oligomerization domain, leucine-rich repeat-containing protein family
(NLR) are intracellular pathogen recognition receptors mediating innate immunity, releasing …

Background Innate immune responses against infectious agents can act as triggers of
inflammatory diseases. On the other hand, various pathogens have developed mechanisms …

Zoonotic visceral leishmaniosis caused by Leishmania infantum is an endemic disease in
the Mediterranean Basin affecting mainly humans and dogs, the main reservoir. The …

Data on cellular immunity mediators in the early phase of human leishmaniasis are still
limited and controversial. In order to mimic the changes of humoral mediators during the …

This study aimed to investigate the effects of parasite antigens on Alzheimer's symptoms in
animal model. Alzheimer's model was induced in Wistar rats using Amyloid-beta peptide …

Because our immune system has ability to expel microorganisms invading our body,
parasites need evolution to maintain their symbiosis with the hosts. One such strategy of the …