Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE.
The pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The …

Macrophages are found in normal kidney and in increased numbers in diseased kidney,
where they act as key players in renal injury, inflammation, and fibrosis. Macrophages are …

The term ferroptosis coined in 2012 causes acute kidney injury (AKI). However, its pathway
mechanism in AKI is poorly understood. In this study, we conducted an RNA-sequence …

Despite marked improvements in the survival of patients with severe lupus nephritis over the
past 50 years, the rate of complete clinical remission after immune suppression therapy is< …

Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …

Macrophage polarization refers to development of a specific phenotype important for tissue
homeostasis or host defense in response to environmental cues. Environmental factors that …

Kidney involvement in patients with systemic lupus erythematosus—lupus nephritis (LN)—is
one of the most important and common clinical manifestations of this disease and occurs in …

Macrophages originating from the yolk sac or bone marrow play essential roles in tissue
homeostasis and disease. Bone marrow-derived monocytes differentiate into Ly6Chi and …

Lupus nephritis (LN) is a common manifestation of systemic lupus erythematosus that can
lead to irreversible renal impairment. Although the prognosis of LN has improved …

Renal dendritic cells (DCs) and macrophages represent a constitutive, extensive and
contiguous network of innate immune cells that provide sentinel and immune-intelligence …