Therapeutic effects of mesenchymal stromal cells require mitochondrial transfer and quality control

AN Mukkala, M Jerkic, Z Khan, K Szaszi… - International Journal of …, 2023 - mdpi.com
Due to their beneficial effects in an array of diseases, Mesenchymal Stromal Cells (MSCs)
have been the focus of intense preclinical research and clinical implementation for decades …

Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord …

R Shen, Y Lu, C Cai, Z Wang, J Zhao, Y Wu… - Stem Cell Research & …, 2024 - Springer
Over the past decade, we have witnessed the development of cell transplantation as a new
strategy for repairing spinal cord injury (SCI). However, due to the complexity of the central …

Mitochondria as secretory organelles and therapeutic cargos

J Suh, YS Lee - Experimental & Molecular Medicine, 2024 - nature.com
Mitochondria have been primarily considered intracellular organelles that are responsible
for generating energy for cell survival. However, accumulating evidence suggests that …

Stroke studies in large animals: Prospects of mitochondrial transplantation and enhancing efficiency using hydrogels and nanoparticle-assisted delivery

O Ulger, I Eş, CM Proctor, O Algin - Ageing Research Reviews, 2024 - Elsevier
One of the most frequent reasons of mortality and disability today is acute ischemic stroke,
which occurs by an abrupt disruption of cerebral circulation. The intricate damage …

Platelet mitochondria, a potent immune mediator in neurological diseases

Y Ma, Q Jiang, B Yang, X Hu, G Shen, W Shen… - Frontiers in …, 2023 - frontiersin.org
Dysfunction of the immune response is regarded as a prominent feature of neurological
diseases, including neurodegenerative diseases, malignant tumors, acute neurotraumatic …

Skeletal muscle dysfunction in amyotrophic lateral sclerosis: a mitochondrial perspective and therapeutic approaches

GB Kubat, P Picone - Neurological Sciences, 2024 - Springer
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disease that
results in the loss of motor neurons and severe skeletal muscle atrophy. The etiology of ALS …

Biomaterials and tissue engineering in traumatic brain injury: novel perspectives on promoting neural regeneration

S Zhu, X Liu, X Lu, Q Liao, H Luo, Y Tian… - Neural Regeneration …, 2024 - journals.lww.com
Traumatic brain injury is a serious medical condition that can be attributed to falls, motor
vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and …

Highly specialized mechanisms for mitochondrial transport in neurons: from intracellular mobility to intercellular transfer of mitochondria

M Zaninello, C Bean - Biomolecules, 2023 - mdpi.com
The highly specialized structure and function of neurons depend on a sophisticated
organization of the cytoskeleton, which supports a similarly sophisticated system to traffic …

[HTML][HTML] Human amniotic mesenchymal stromal cell-derived exosomes promote neuronal function by inhibiting excessive apoptosis in a hypoxia/ischemia-induced …

Y Zhou, LN He, LN Wang, KY Chen, SD Qian… - Biomedicine & …, 2024 - Elsevier
Background Cerebral palsy (CP) is a condition resulting from perinatal brain injury and can
lead to physical disabilities. Exosomes derived from human amniotic mesenchymal stromal …

Mitochondrial transplantation and transfer: The promising method for diseases

GB Kubat - Turkish Journal of Biology, 2023 - journals.tubitak.gov.tr
Mitochondria are organelles that serve as the powerhouses for cellular bioenergetics in
eukaryotic cells. It is responsible for mitochondrial adenosine triphosphate (ATP) generation …