Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

The sarcoendoplasmic reticulum (SR) calcium transport ATPase (SERCA) is a pump that
transports calcium ions from the cytoplasm into the SR. It is present in both animal and plant …

Background During the development of heart failure (HF), the chief myocardial energy
substrate switches from fatty acids to glucose. This metabolic switch, which recapitulates …

The definition of whether and how advancing age affects cardiovascular structure and
function is a formidable research endeavor because other factors that covary with age, ie …

Simmerman, Heather KB, and Larry R. Jones. Phospholamban: Protein Structure,
Mechanism of Action, and Role in Cardiac Function. Physiol. Rev. 78: 921–947, 1998.—A …

Cardiac hypertrophy is a well known response to increased hemodynamic load. Mechanical
stress is considered to be the trigger inducing a growth response in the overloaded …

Background Previous studies provide considerable evidence that excitation-contraction
coupling may be disturbed at the level of the sarcoplasmic reticulum (SR) in the failing …

of transport into the mitochondrion (eg, because of excessive fatty acid availability and/or
CPTI inhibition by malonyl-CoA), cytosolic LCFACoA levels increase. The latter are utilized …

The sarco (endo) plasmic reticulum calcium ATPase (SERCA) is responsible for transporting
calcium (Ca2+) from the cytosol into the lumen of the sarcoplasmic reticulum (SR) following …

Recent studies have shown that intracellular Ca2+ handling is abnormal in the myocardium
of patients with end-stage heart failure. Muscles from the failing hearts showed a prolonged …