Reverse vaccinology: developing vaccines in the era of genomics
A Sette, R Rappuoli - Immunity, 2010 - cell.com
The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
Evolutionary analysis of the dynamics of viral infectious disease
Many organisms that cause infectious diseases, particularly RNA viruses, mutate so rapidly
that their evolutionary and ecological behaviours are inextricably linked. Consequently …
that their evolutionary and ecological behaviours are inextricably linked. Consequently …
Efficient control of population structure in model organism association mapping
Genomewide association mapping in model organisms such as inbred mouse strains is a
promising approach for the identification of risk factors related to human diseases. However …
promising approach for the identification of risk factors related to human diseases. However …
Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies
MS Seaman, H Janes, N Hawkins, LE Grandpre… - Journal of …, 2010 - Am Soc Microbiol
The restricted neutralization breadth of vaccine-elicited antibodies is a major limitation of
current human immunodeficiency virus-1 (HIV-1) candidate vaccines. In order to permit the …
current human immunodeficiency virus-1 (HIV-1) candidate vaccines. In order to permit the …
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
N Goonetilleke, MKP Liu… - Journal of experimental …, 2009 - rupress.org
Identification of the transmitted/founder virus makes possible, for the first time, a genome-
wide analysis of host immune responses against the infecting HIV-1 proteome. A complete …
wide analysis of host immune responses against the infecting HIV-1 proteome. A complete …
HIV-1 neutralizing antibody signatures and application to epitope-targeted vaccine design
Eliciting HIV-1-specific broadly neutralizing antibodies (bNAbs) remains a challenge for
vaccine development, and the potential of passively delivered bNAbs for prophylaxis and …
vaccine development, and the potential of passively delivered bNAbs for prophylaxis and …
Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies
M Bonsignori, EF Kreider, D Fera… - Science translational …, 2017 - science.org
A preventive HIV-1 vaccine should induce HIV-1–specific broadly neutralizing antibodies
(bnAbs). However, bnAbs generally require high levels of somatic hypermutation (SHM) to …
(bnAbs). However, bnAbs generally require high levels of somatic hypermutation (SHM) to …
No evidence for distinct types in the evolution of SARS-CoV-2
A recent study by Tang et al. claimed that two major types of severe acute respiratory
syndrome-coronavirus-2 (CoV-2) had evolved in the ongoing CoV disease-2019 pandemic …
syndrome-coronavirus-2 (CoV-2) had evolved in the ongoing CoV disease-2019 pandemic …
Adaptation of HIV-1 to human leukocyte antigen class I
Y Kawashima, K Pfafferott, J Frater, P Matthews… - Nature, 2009 - nature.com
The rapid and extensive spread of the human immunodeficiency virus (HIV) epidemic
provides a rare opportunity to witness host–pathogen co-evolution involving humans. A focal …
provides a rare opportunity to witness host–pathogen co-evolution involving humans. A focal …
Correlating viral phenotypes with phylogeny: accounting for phylogenetic uncertainty
Many recent studies have sought to quantify the degree to which viral phenotypic characters
(such as epidemiological risk group, geographic location, cell tropism, drug resistance state …
(such as epidemiological risk group, geographic location, cell tropism, drug resistance state …