Cell migration is an adaptive process that depends on and responds to physical and
molecular triggers. Moving cells sense and respond to tissue mechanics and induce …

Collective cell migration results from the establishment and maintenance of collective
polarization, mechanocoupling, and cytoskeletal kinetics. The guidance of collective cell …

Patients with mammographically dense breast tissue have a greatly increased risk of
developing breast cancer. Dense breast tissue contains more stromal collagen, which …

Directed migration by contact guidance is a poorly understood yet vital phenomenon,
particularly for carcinoma cell invasion on aligned collagen fibres. We demonstrate that for …

Cell migration underlies tissue formation, maintenance, and regeneration as well as
pathological conditions such as cancer invasion. Structural and molecular determinants of …

The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial
and mechanical cues to which cells respond. In addition to soluble chemical factors …

Cells generate mechanical force to organize the extracellular matrix (ECM) and drive
important developmental and reparative processes. Likewise, tumor cells invading into three …

Cell migration in three-dimensional (3-D) extracellular matrix (ECM) is not a uniform event
but rather comprises a modular spectrum of interdependent biophysical and biochemical …

Abstract Model systems mimicking the extracellular matrix (ECM) have greatly helped in
quantifying cell migration in three dimensions and elucidated the molecular determinants of …

This highly unusual book began as a serious inquiry into Schr dinger's question,? What is
life??, and as a celebration of life itself. It takes the reader on a voyage of discovery through …