The high strain diversity of Streptococcus pyogenes serves as a major obstacle to vaccine
development against this leading global pathogen. We did a systematic review of studies in …

Streptococcus pyogenes (group A Streptococcus; GAS), a Gram-positive coccal bacterium,
poses a significant global disease burden, especially in low-and middle-income countries …

The UK observed a marked increase in scarlet fever and invasive group A streptococcal
infection in 2022 with severe outcomes in children and similar trends worldwide. Here we …

We have developed GmPcides from a peptidomimetic dihydrothiazolo ring-fused 2-pyridone
scaffold that has antimicrobial activities against a broad spectrum of Gram-positive …

Immunoglobulin (Ig) A functions as monomeric IgA in the serum and Secretory (S) IgA in
mucosal secretions. Host IgA Fc receptors (FcαRs), including human FcαR1/CD89, mediate …

The germ theory states that pathogenic microorganisms are responsible for causing
infectious diseases. The theory is inherently microbe-centric and does not account for …

This study aims to provide a comparison of the current recommendations about the
management of acute pharyngitis. A literature search was conducted from January 2009 to …

SUMMARY Group A Streptococcus (GAS), also known as Streptococcus pyogenes, is a
clinically well-adapted human pathogen that harbors rich virulence determinants …

While genome-wide transposon mutagenesis screens have identified numerous essential
genes in the significant human pathogen Streptococcus pyogenes (group A Streptococcus …

Epidemiological data have indicated that invasive infections caused by the Gram-positive
cocci Streptococcus pyogenes (group A streptococcus, GAS) have increased in many …