Benefits and limitations of genome-wide association studies

V Tam, N Patel, M Turcotte, Y Bossé, G Paré… - Nature Reviews …, 2019 - nature.com
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

Tracing the peopling of the world through genomics

R Nielsen, JM Akey, M Jakobsson, JK Pritchard… - Nature, 2017 - nature.com
Advances in the sequencing and the analysis of the genomes of both modern and ancient
peoples have facilitated a number of breakthroughs in our understanding of human …

On the limits of fitting complex models of population history to f-statistics

R Maier, P Flegontov, O Flegontova, U Işıldak… - Elife, 2023 - elifesciences.org
Our understanding of population history in deep time has been assisted by fitting admixture
graphs (AGs) to data: models that specify the ordering of population splits and mixtures …

Genomic insights into the formation of human populations in East Asia

CC Wang, HY Yeh, AN Popov, HQ Zhang… - Nature, 2021 - nature.com
The deep population history of East Asia remains poorly understood owing to a lack of
ancient DNA data and sparse sampling of present-day people,. Here we report genome …

The source of the Black Death in fourteenth-century central Eurasia

MA Spyrou, L Musralina, GA Gnecchi Ruscone… - Nature, 2022 - nature.com
The origin of the medieval Black Death pandemic (ad 1346–1353) has been a topic of
continuous investigation because of the pandemic's extensive demographic impact and long …

Grey wolf genomic history reveals a dual ancestry of dogs

A Bergström, DWG Stanton, UH Taron, L Frantz… - Nature, 2022 - nature.com
The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and
they remained widespread throughout the last Ice Age when many other large mammal …

The genetic history of the Southern Arc: A bridge between West Asia and Europe

I Lazaridis, S Alpaslan-Roodenberg, A Acar, A Açıkkol… - Science, 2022 - science.org
By sequencing 727 ancient individuals from the Southern Arc (Anatolia and its neighbors in
Southeastern Europe and West Asia) over 10,000 years, we contextualize its Chalcolithic …

[图书][B] Who we are and how we got here: Ancient DNA and the new science of the human past

D Reich - 2018 - books.google.com
The past few years have witnessed a revolution in our ability to obtain DNA from ancient
humans. This important new data has added to our knowledge from archaeology and …

The formation of human populations in South and Central Asia

VM Narasimhan, N Patterson, P Moorjani, N Rohland… - Science, 2019 - science.org
RATIONALE To elucidate the extent to which the major cultural transformations of farming,
pastoralism, and shifts in the distribution of languages in Eurasia were accompanied by …

[HTML][HTML] Human demographic history impacts genetic risk prediction across diverse populations

AR Martin, CR Gignoux, RK Walters, GL Wojcik… - The American Journal of …, 2017 - cell.com
The vast majority of genome-wide association studies (GWASs) are performed in
Europeans, and their transferability to other populations is dependent on many factors (eg …