Molecules containing 3-substituted isobenzofuranones and isoindolinones skeletons are
found in important bioactive compounds and in a number of natural products. As a …

We describe the most common methods for the asymmetric construction of the isoindolinone
ring system. The discussion begins with early methodologies based on the resolution of …

A unique reactivity pattern, first observed in the conversion of the marine natural product
pestalone into pestalachloride A, was investigated. It was shown that 2-formyl-arylketones …

The multimetallic iridium‐tritin (Ir‐Sn3) complex [Cp* Ir (SnCl3) 2 {SnCl2 (H2O) 2}](1) proved
to be a highly effective catalyst towards C OH bond activation of γ‐hydroxylactams, leading …

Structure–activity relationships for the MDM2-p53 inhibitory activity of a series of A-ring
substituted 2-N-benzyl-3-(4-chlorophenyl)-3-(1-(hydroxymethyl) cyclopropyl) methoxy) …

Copper‐catalyzed cascade transformations of 2‐formylbenzonitrile and diaryliodonium salts
were carried out to efficiently afford isoindolin‐1‐one scaffolds. The process proceeds …

A highly efficient and accessible synthesis of chiral 3-substituted isoindolinone frameworks
is described. The synthesis involved the Rh (I)-catalyzed asymmetric arylation of boronic …

A copper-catalyzed aerobic 3-hydroxyisoindolinone synthesis was developed via the
benzylic double C (sp3)–H functionalization of 2-alkylbenzamides. In this reaction …

This account describes our recent studies on the development of chiral nonracemic cyclic
imide-based synthetic methodology and the complementary N-α-carbanion synthon-based …

An efficient and convenient access to 2-tert-butylisoindolin-1-ones via an oxidative radical
cyclization process from stable carbamoylxanthates, derived from secondary tert …