2021 European Heart Rhythm Association practical guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation

J Steffel, R Collins, M Antz, P Cornu, L Desteghe… - Ep …, 2021 - academic.oup.com
1Department of Cardiology, Division of Electrophysiology, University Heart Center Zurich,
Switzerland; 2Age-Related Health Care, Tallaght University Hospital/Department of …

[HTML][HTML] Autoimmune heparin‐induced thrombocytopenia

A Greinacher, K Selleng, TE Warkentin - Journal of Thrombosis and …, 2017 - Elsevier
Autoimmune heparin‐induced thrombocytopenia (aHIT) indicates the presence in patients of
anti‐platelet factor 4 (PF4)–polyanion antibodies that are able to activate platelets strongly …

Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association

JF Meschia, C Bushnell, B Boden-Albala, LT Braun… - Stroke, 2014 - Am Heart Assoc
The aim of this updated statement is to provide comprehensive and timely evidence-based
recommendations on the prevention of stroke among individuals who have not previously …

Heparin-induced thrombocytopenia

A Greinacher - New England Journal of Medicine, 2015 - Mass Medical Soc
Key Clinical Points Heparin-Induced Thrombocytopenia Heparin-induced thrombocytopenia
(HIT) is characterized by a decrease in the platelet count of more than 50% from the highest …

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

KW Witwer, EI Buzás, LT Bemis, A Bora… - Journal of …, 2013 - Taylor & Francis
The emergence of publications on extracellular RNA (exRNA) and extracellular vesicles
(EV) has highlighted the potential of these molecules and vehicles as biomarkers of disease …

The pathophysiology of thrombocytopenia in chronic liver disease

O Mitchell, DM Feldman, M Diakow… - … medicine: evidence and …, 2016 - Taylor & Francis
Thrombocytopenia is the most common hematological abnormality encountered in patients
with chronic liver disease (CLD). In addition to being an indicator of advanced disease and …

Direct oral anticoagulants for treatment of HIT: update of Hamilton experience and literature review

TE Warkentin, M Pai, LA Linkins - Blood, The Journal of the …, 2017 - ashpublications.org
Direct oral anticoagulants (DOACs) are attractive options for treatment of heparin-induced
thrombocytopenia (HIT). We report our continuing experience in Hamilton, ON, Canada …

Targeting CXCR4 in AML and all

D Cancilla, MP Rettig, JF DiPersio - Frontiers in oncology, 2020 - frontiersin.org
The interaction of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
blasts with the bone marrow microenvironment regulates self-renewal, growth signaling, as …

How I treat heparin-induced thrombocytopenia

A Cuker, DB Cines - Blood, The Journal of the American …, 2012 - ashpublications.org
Heparin-induced thrombocytopenia is a prothrombotic adverse drug effect induced by
platelet-activating antibodies against multimolecular complexes of platelet factor 4 and …

Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity

TH Nguyen, N Medvedev, M Delcea… - Nature …, 2017 - nature.com
Antibodies recognizing complexes of the chemokine platelet factor 4 (PF4/CXCL4) and
polyanions (P) opsonize PF4-coated bacteria hereby mediating bacterial host defense. A …