Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …
molecule are basically designed to interact with multiple targets or to amplify its effect …
A review: Biologically active 3, 4-heterocycle-fused coumarins
The combination of heterocycles offers a new opportunity to create novel multicyclic
compounds having improved biological activity. Coumarins are ubiquitous natural …
compounds having improved biological activity. Coumarins are ubiquitous natural …
Lamellarins and related pyrrole-derived alkaloids from marine organisms
Marine organisms have proven to be rich sources of unique alkaloids. In earlier surveys we
comprehensively reviewed several intriguing groups of marine alkaloids, including the …
comprehensively reviewed several intriguing groups of marine alkaloids, including the …
Synthesis and biological activity of pyrrole, pyrroline and pyrrolidine derivatives with two aryl groups on adjacent positions
F Bellina, R Rossi - Tetrahedron, 2006 - Elsevier
Five-membered heterocycle derivatives with two aryl groups on adjacent positions include
several classes of natural and unnatural compounds that exhibit a variety of biological and …
several classes of natural and unnatural compounds that exhibit a variety of biological and …
[HTML][HTML] Overview of P-glycoprotein inhibitors: a rational outlook
KMR Srivalli, PK Lakshmi - Brazilian Journal of Pharmaceutical …, 2012 - SciELO Brasil
P-glycoprotein (P-gp), a transmembrane permeability glycoprotein, is a member of ATP
binding cassette (ABC) super family that functions specifically as a carrier mediated primary …
binding cassette (ABC) super family that functions specifically as a carrier mediated primary …
Marine natural products
Covering: 2005. Previous review: Nat. Prod. Rep., 2006, 23, 26 This review covers the
literature published in 2005 for marine natural products, with 704 citations (493 for the …
literature published in 2005 for marine natural products, with 704 citations (493 for the …
Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer
The biggest challenge associated with cancer chemotherapy is the development of cross
multi-drug resistance to almost all anti-cancer agents upon chronic treatment. The major …
multi-drug resistance to almost all anti-cancer agents upon chronic treatment. The major …
Anticancer properties of lamellarins
C Bailly - Marine Drugs, 2015 - mdpi.com
In 1985 the first lamellarins were isolated from a small oceanic sea snail. Today, more than
50 lamellarins have been inventoried and numerous derivatives synthesized and tested as …
50 lamellarins have been inventoried and numerous derivatives synthesized and tested as …
Revisiting the ABCs of multidrug resistance in cancer chemotherapy
The adenosine triphosphate binding cassette (ABC) transporters are one of the largest
transmembrane gene families in humans. The ABC transporters are present in a number of …
transmembrane gene families in humans. The ABC transporters are present in a number of …
Molecular determinants of topoisomerase I poisoning by Lamellarins: Comparison with Camptothecin and structure− activity relationships
E Marco, W Laine, C Tardy, A Lansiaux… - Journal of medicinal …, 2005 - ACS Publications
A series of lamellarin derivatives have been studied as topoisomerase I (Top1) inhibitors.
Molecular models of the ternary complexes formed between the DNA-Top1 ensemble and …
Molecular models of the ternary complexes formed between the DNA-Top1 ensemble and …