Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

Cell–matrix adhesion is crucial for maintaining the mechanical integrity of epithelial tissues.
Podocytes—a key component of the glomerular filtration barrier—are exposed to permanent …

Podocytes are specialized epithelial cells of the kidney blood filtration barrier that contribute
to permselectivity via a series of interdigitating actin–rich foot processes. Positioned …

Myosins are cytoskeletal motor proteins that use energy derived from ATP hydrolysis to
generate force and movement along actin filaments. Humans express 38 myosin genes …

A glomerulus is the network of capillaries that resides in the Bowman's capsule that
functions as a filtration unit of kidney. The glomerular function ensures that essential plasma …

Epithelial cells exfoliated in human urine can include cells anywhere from the urinary tract
and kidneys; however, podocytes and proximal tubular epithelial cells (PTECs) are by far the …

Background Mutations in podocyte and basement membrane genes are associated with a
growing spectrum of glomerular disease affecting adults and children. Investigation of …

Despite advancing therapies, thousands of women die every year of breast cancer. Myosins,
actin-dependent molecular motors, are likely to contribute to tumor formation and metastasis …

More than 60 monogenic genes mutated in steroid-resistant nephrotic syndrome (SRNS)
have been identified. Our previous study found that mutations in nucleoporin 160 kD …

Long-tailed unconventional class I myosin, Myosin 1E (MYO1E) and Myosin 1F (MYO1F) are
motor proteins that use chemical energy from the hydrolysis of adenosine triphosphate …