Extracellular vesicles (EVs), such as exosomes and microvesicles, have over the last 10–15
years been recognized to convey key messages in the molecular communication between …

Poly (ADP-ribosylation) is a post-translational modification of proteins playing a crucial role
in many processes, including DNA repair and cell death. The best known poly (ADP …

High mobility group box 1 protein (HMGB1) is a non-histone nuclear protein with dual
function. Inside the cell, HMGB1 binds DNA and regulates transcription, whereas outside the …

Extracellular vesicles (EVs) are lipid bilayer‐enclosed subcellular bodies produced by most,
if not all cells. Research over the last two decades has recognised the importance of EVs in …

Background: Several recent reports have described the detection of circulating, cancer-
related RNA molecules in serum or plasma from cancer patients, but little is known about the …

Nonresonant confocal Raman imaging has been used to map the DNA and the protein
distributions in individual single human cells. The images are obtained on an improved …

Apoptosis is involved in morphogenesis of embryonic tissues as well as in homeostasis of
adult organs and tissues. It is the main process by which organs maintain cell mass and at …

Apoptosis is characterized by a complex and remarkably ordered choreography of events
consisting of the preparatory and execution steps that all culminate in disposal of the cell …

Normal arteries are characterized by a low turnover of endothelial (EC) and smooth muscle
cells (SMC). Different mechanisms protect the EC and SMC against apoptosis in the normal …

Poly (ADP-ribose) polymerase-1 (PARP-1) plays the active role of “nick sensor” during DNA
repair and apoptosis, when it synthesizes ADP-ribose from NAD+ in the presence of DNA …