Magnetic resonance imaging and spectroscopic techniques are widely used in humans both
for clinical diagnostic applications and in basic research areas such as cognitive …

Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …

The past decades of advancements in NMR have made it a very powerful tool for metabolic
research. Despite its limitations in sensitivity relative to mass spectrometric techniques, NMR …

Although glutamate is usually thought of as the major excitatory neurotransmitter in brain, it
is important to note that glutamate has many other fates in brain, including oxidation for …

MR spectroscopic imaging (MRSI) has become a valuable tool for quantifying metabolic
abnormalities in human brain, prostate, breast and other organs. It is used in routine clinical …

Many imaging methods have been proposed to act as surrogate markers of organ damage,
yet for many candidates the essential biomarkers characteristics of the injured organ have …

Proton NMR spectroscopy is emerging from translational and preclinical neuroscience
research as an important tool for evidence based diagnosis and therapy monitoring. It …

Quantitative assessment of cerebral glucose consumption rate (CMRglc) and tricarboxylic
acid cycle flux (VTCA) is crucial for understanding neuroenergetics under …

Advances in analytical methodologies, principally nuclear magnetic resonance
spectroscopy (NMR) and mass spectrometry (MS), during the last decade have made large …

In vitro and in vivo studies have shown that glutamate can be oxidized for energy by brain
astrocytes. The ability to harvest the energy from glutamate provides astrocytes with a …