[HTML][HTML] IL-12 family cytokines in cancer and immunotherapy
B Mirlekar, Y Pylayeva-Gupta - Cancers, 2021 - mdpi.com
Simple Summary The IL-12 family cytokines play an important role in regulating the tumor
immune contexture. Recent efforts geared towards the development of better immune …
immune contexture. Recent efforts geared towards the development of better immune …
[HTML][HTML] SOCS3, a major regulator of infection and inflammation
B Carow, ME Rottenberg - Frontiers in immunology, 2014 - frontiersin.org
In this review, we describe the role of suppressor of cytokine signaling-3 (SOCS3) in
modulating the outcome of infections and autoimmune diseases as well as the underlying …
modulating the outcome of infections and autoimmune diseases as well as the underlying …
The immunobiology of interleukin-27
H Yoshida, CA Hunter - Annual review of immunology, 2015 - annualreviews.org
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune
response. Although it was initially linked with the development of Th1 responses, it is now …
response. Although it was initially linked with the development of Th1 responses, it is now …
IL-27-induced modulation of autoimmunity and its therapeutic potential
Abstract Interleukin-27 (IL-27) is a new member of the IL-12 family. It is produced by
activated antigen-presenting cells and plays an important role in the regulation of CD4+ T …
activated antigen-presenting cells and plays an important role in the regulation of CD4+ T …
[HTML][HTML] IL-27, IL-30, and IL-35: a cytokine triumvirate in cancer
The role of the immune system in anti-tumor immunity cannot be overstated, as it holds the
potential to promote tumor eradication or prevent tumor cell escape. Cytokines are critical to …
potential to promote tumor eradication or prevent tumor cell escape. Cytokines are critical to …
Dual roles of IL‐27 in cancer biology and immunotherapy
IL‐27 is a pleiotropic two‐chain cytokine, composed of EBI3 and IL‐27p28 subunits, which is
structurally related to both IL‐12 and IL‐6 cytokine families. IL‐27 acts through a …
structurally related to both IL‐12 and IL‐6 cytokine families. IL‐27 acts through a …
[HTML][HTML] Anti-viral CD8 T cells and the cytokines that they love
MA Cox, SM Kahan, AJ Zajac - Virology, 2013 - Elsevier
Viral infections cause an immunological disequilibrium that provokes CD8 T cell responses.
These cells play critical roles in purging acute infections, limiting persistent infections, and …
These cells play critical roles in purging acute infections, limiting persistent infections, and …
Tumor-derived IL-35 promotes tumor growth by enhancing myeloid cell accumulation and angiogenesis
Z Wang, JQ Liu, Z Liu, R Shen, G Zhang… - The Journal of …, 2013 - journals.aai.org
IL-35 is a member of the IL-12 family of cytokines that is comprised of an IL-12 p35 subunit
and an IL-12 p40-related protein subunit, EBV-induced gene 3 (EBI3). IL-35 functions …
and an IL-12 p40-related protein subunit, EBV-induced gene 3 (EBI3). IL-35 functions …
[HTML][HTML] Selective loss of function variants in IL6ST cause Hyper-IgE syndrome with distinct impairments of T-cell phenotype and function
Hyper-IgE syndromes comprise a group of inborn errors of immunity. STAT3-deficient hyper-
IgE syndrome is characterized by elevated serum IgE levels, recurrent infections and …
IgE syndrome is characterized by elevated serum IgE levels, recurrent infections and …
[HTML][HTML] Heterogenous CD8+ T cell maturation and 'polarization'in acute and convalescent COVID-19 patients
IV Kudryavtsev, NA Arsentieva, ZR Korobova… - Viruses, 2022 - mdpi.com
Background. The adaptive antiviral immune response requires interaction between CD8+ T
cells, dendritic cells, and Th1 cells for controlling SARS-CoV-2 infection, but the data …
cells, dendritic cells, and Th1 cells for controlling SARS-CoV-2 infection, but the data …