In exploring persistent infections and malignancies, a distinctive subgroup of CD8+ T cells,
progenitor exhausted CD8+ T (Tpex) cells, has been identified. These Tpex cells are notable …

Objective To evaluate the predictive value of PD-1 expression in T lymphocytes for
rehospitalization due to acute exacerbations of COPD (AECOPD) in discharged patients …

Generation of functional CD8+ T cell memory typically requires engagement of CD4+ T cells.
However, in certain scenarios, such as acutely-resolving viral infections, effector (TE) and …

Natural Killer (NK) cells are promising tools for the development of immunotherapies
targeting persistently infected CD4+ T cells to potentially achieve remission in people with …

Epigenetic mechanisms stabilize gene expression patterns during CD8+ T cell
differentiation. However, although adoptive transfer of virus-specific T cells is clinically …

Background Humanized tumor models could be particularly valuable for cancer
immunotherapy research, as they may better reflect human-specific aspects of the interfaces …

Tuberculosis (TB) is a disease that has evolved with humankind for millennia, causing
approximately 1.3 million deaths worldwide per annum. Although increased male affliction …

During prolonged antigen exposure, as in cancer or HIV, surface inhibitory receptors called
immune checkpoints (ICs), like Lymphocyte Activation Gene-3 (LAG3) are upregulated on T …

Abstract 1 The functional relevance of CD8+ T cell phenotypes in human cancer is not well
established. 2 In preclinical studies, murine CD8+ T cells exhibiting an exhausted-like …

Abstract Programmed death ligand-1 (PD-L1) is a key component of tumor
immunosuppression. The uneven therapeutic results of PD-L1 therapy have stimulated …