Nitric oxide (NO) is a well-known gaseous mediator that maintains vascular homeostasis.
Extensive evidence supports that a hallmark of endothelial dysfunction, which leads to …

Intracellular signaling mechanisms in red blood cells (RBCs) involve various protein kinases
and phosphatases and enable rapid adaptive responses to hypoxia, metabolic …

Background Epithelial-mesenchymal transition (EMT) occurs in the tumor microenvironment
and presents an important mechanism of tumor cell intravasation, stemness acquisition, and …

Abstract Vγ9Vδ2 T cells are activated by phosphoantigens, such as isopentenyl
pyrophosphate (IPP), which is generated in the mevalonate pathway of antigen-presenting …

Background and aims Absolute coronary flow can be measured by intracoronary continuous
thermodilution of saline through a dedicated infusion catheter (RayFlow®). A saline infusion …

Nitric oxide (NO) appears to be involved in virtually every aspect of cardiovascular biology.
Most attention has been focused on the role of endothelial-derived NO in basal blood flow …

Background: Erythrocytes (red blood cells) participate in the control of vascular NO
bioavailability. The purpose of this study was to determine whether and how genetic deletion …

There is accumulating evidence that biological membranes are not just homogenous lipid
structures, but are highly organized in microdomains, ie compartmentalized areas of protein …

In vitro investigations demonstrate that human erythrocytes synthesize nitric oxide via a
functional isoform of endothelial nitric oxide synthase (NOS)(RBC-NOS). We tested the …

The classic view of the red blood cell (RBC) presents a biologically inert cell that upon
maturation has limited capacity to alter its physical properties. This view developed largely …