Glucocorticoid circadian rhythms in immune function
Adrenal glucocorticoid (GC) hormones are important regulators of energy metabolism, brain
functions, and the immune system. Their release follows robust diurnal rhythms and GCs …
functions, and the immune system. Their release follows robust diurnal rhythms and GCs …
Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth
MD Taves, S Otsuka, MA Taylor… - The Journal of …, 2023 - Am Soc Clin Investig
Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their
primary source is the adrenals, where they are generated via de novo synthesis from …
primary source is the adrenals, where they are generated via de novo synthesis from …
Profiling of systemic and brain steroids in male songbirds: Seasonal changes in neurosteroids
C Jalabert, C Ma, KK Soma - Journal of neuroendocrinology, 2021 - Wiley Online Library
Steroids are secreted by the gonads and adrenal glands into the blood to modulate
neurophysiology and behaviour. In addition, the brain can metabolise circulating steroids …
neurophysiology and behaviour. In addition, the brain can metabolise circulating steroids …
Prolonged social isolation, started early in life, impairs cognitive abilities in rats depending on sex
NA Krupina, SD Shirenova, NN Khlebnikova - Brain sciences, 2020 - mdpi.com
Background: The chronic stress of social isolation is a valid predictor of cognitive pathology.
This study aimed to compare the effects of long-term social isolation on female versus male …
This study aimed to compare the effects of long-term social isolation on female versus male …
The unconditioned fear response in dystrophin-deficient mice is associated with adrenal and vascular function
A Lindsay, AP Russell - Scientific Reports, 2023 - nature.com
Loss of function mutations in the gene encoding dystrophin elicits a hypersensitive fear
response in mice and humans. In the dystrophin-deficient mdx mouse, this behaviour is …
response in mice and humans. In the dystrophin-deficient mdx mouse, this behaviour is …
Steroid profiling of glucocorticoids in microdissected mouse brain across development
JE Hamden, KM Gray, M Salehzadeh… - Developmental …, 2021 - Wiley Online Library
Corticosterone is produced by the adrenal glands and also produced locally by other
organs, such as the brain. Local levels of corticosterone in specific brain regions during …
organs, such as the brain. Local levels of corticosterone in specific brain regions during …
Androgen synthesis inhibition increases behavioural flexibility and mPFC tyrosine hydroxylase in gonadectomized male rats
Behavioural flexibility is essential to adapt to a changing environment and depends on the
medial prefrontal cortex (mPFC). Testosterone administration decreases behavioural …
medial prefrontal cortex (mPFC). Testosterone administration decreases behavioural …
SteroidXtract: deep learning-based pattern recognition enables comprehensive and rapid extraction of steroid-like metabolic features for automated biology-driven …
Despite the vast amount of metabolic information that can be captured in untargeted
metabolomics, many biological applications are looking for a biology-driven metabolomics …
metabolomics, many biological applications are looking for a biology-driven metabolomics …
LC-APCI+-MS/MS method for the analysis of ten hormones and two endocannabinoids in plasma and hair from the mice with different gut microbiota
L Chu, N Li, J Deng, Y Wu, H Yang, W Wang… - … of pharmaceutical and …, 2020 - Elsevier
The effect of gut microbiota on the activity of the HPA and HPG axes and ECS is a short-term
or long-lasting process remains unclear in rodents. However, the extant studies focused only …
or long-lasting process remains unclear in rodents. However, the extant studies focused only …
Glucocorticoid production in lymphoid organs: acute effects of lipopolysaccharide in neonatal and adult mice
M Salehzadeh, JE Hamden, MX Li, H Bajaj… - …, 2022 - academic.oup.com
Glucocorticoids (GCs) are critical modulators of the immune system. The hypothalamic-
pituitary-adrenal (HPA) axis regulates circulating GC levels and is stimulated by endotoxins …
pituitary-adrenal (HPA) axis regulates circulating GC levels and is stimulated by endotoxins …