Adrenal glucocorticoid (GC) hormones are important regulators of energy metabolism, brain
functions, and the immune system. Their release follows robust diurnal rhythms and GCs …

Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their
primary source is the adrenals, where they are generated via de novo synthesis from …

Steroids are secreted by the gonads and adrenal glands into the blood to modulate
neurophysiology and behaviour. In addition, the brain can metabolise circulating steroids …

Background: The chronic stress of social isolation is a valid predictor of cognitive pathology.
This study aimed to compare the effects of long-term social isolation on female versus male …

Loss of function mutations in the gene encoding dystrophin elicits a hypersensitive fear
response in mice and humans. In the dystrophin-deficient mdx mouse, this behaviour is …

Corticosterone is produced by the adrenal glands and also produced locally by other
organs, such as the brain. Local levels of corticosterone in specific brain regions during …

Behavioural flexibility is essential to adapt to a changing environment and depends on the
medial prefrontal cortex (mPFC). Testosterone administration decreases behavioural …

Despite the vast amount of metabolic information that can be captured in untargeted
metabolomics, many biological applications are looking for a biology-driven metabolomics …

The effect of gut microbiota on the activity of the HPA and HPG axes and ECS is a short-term
or long-lasting process remains unclear in rodents. However, the extant studies focused only …

Glucocorticoids (GCs) are critical modulators of the immune system. The hypothalamic-
pituitary-adrenal (HPA) axis regulates circulating GC levels and is stimulated by endotoxins …