Tumor microenvironment (TME) composes of multiple cell types and non-cellular
components, which supports the proliferation, metastasis and immune surveillance evasion …

T cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) is an aggressive malignancy of
progenitor T cells. Despite significant improvements in survival of T-ALL/LBL over the past …

To date, most studies on the DNA polymerase, POLD1, have focused on the effect of POLD1
inactivation mutations in tumors. However, the implications of high POLD1 expression in …

Background Despite some progress having been made regarding the treatment of T-cell
acute lymphoblastic leukemia (T-ALL), the prognosis of T-ALL, particularly adult T-ALL, is …

Immunomodulatory imide drugs (IMiDs) such as thalidomide, pomalidomide, and
lenalidomide are the most common cereblon (CRBN) recruiters in proteolysis-targeting …

Simple Summary Acute lymphoblastic leukemia is the most frequent tumor in childhood age.
Recently, we associated KCTD protein family members with childhood ALL with particular …

Background: Leukemia, a cancer impacting blood-forming tissues such as bone marrow and
the lymphatic system, presents in various forms, affecting children and adults differently. The …

Metastasis remains the principal cause of cancer-related lethality despite advancements in
cancer treatment. Dysfunctional epigenetic alterations are crucial in the metastatic cascade …

T-cell acute lymphoblastic leukemia (T-ALL) has been plagued by high relapse and mortality
rates due to the lack of available targeted treatment options in the clinic. Herein, a CD7 …

Bromodomain and extraterminal domain protein 2 (BRD2), a member of the bromodomain
and extraterminal domain (BET) protein family, is a crucial epigenetic regulator with …