Chronic stress is one of the key precipitating factors in major depressive disorder (MDD).
Stress associated studies have underscored the mechanistic role of epigenetic master …

Background Chronic stress exposure increases the risk of mental health problems such as
anxiety and depression. The medial prefrontal cortex (mPFC) is a hub for controlling stress …

Major depression is a complex psychiatric disorder characterized by affective, cognitive, and
physiological impairments that lead to maladaptive behavior. The high lifetime prevalence of …

The coronavirus disease 2019 (COVID-19) pandemic has generated a lot of stress and
anxiety among not only infected patients but also the general population across the globe …

There are sex differences in metabolic disease risk, and early-life stress (ES) increases the
risk to develop such diseases, potentially in a sex-specific manner. It remains to be …

Major depressive disorder (MDD) is a chronic and disabling disorder affecting roughly 280
million people worldwide. While multiple brain areas have been implicated, dysfunction of …

Objective. Changes in the brain derived neurotrophic factor (BDNF) and glucocorticoid
receptor (GR) expression in the prefrontal cortex (PFC) and hippocampus (HIP) are …

BKM120 is an inhibitor of class I phosphoinositide 3-kinases and its anti-cancer effects have
been demonstrated in various solid cancer models. BKM120 is highly brain permeable and …

Brain-derived neurotrophic factor (BDNF), is known to promote neuroplastic changes that
facilitate many behaviors and may mitigate the impact of stressor exposure. BDNF signals …

Stress is associated with prefrontal (PFC) hypoactivity and disruption of prefrontal
excitatory/inhibitory (E/I) balance is thought to underlie stress related neuropsychiatric …