The T cell compartment can form a powerful defense against extrinsic (eg, pathogens) and
intrinsic danger (eg, malignant cells). At the same time, specific subsets of T cells control this …

Tuberculosis (TB) vaccine research has reached a unique point in time. Breakthrough
findings in both the basic immunology of Mycobacterium tuberculosis infection and the …

Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the
granuloma. In some granulomas, immune activity promotes bacterial clearance, but in …

Tuberculosis is a significant health problem without an effective vaccine to combat it. A
thorough understanding of the immune response and correlates of protection is needed to …

Background The prevalence of tuberculosis among men who work in the gold mines of
South Africa is among the highest in the world, but a fraction of miners demonstrate …

Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with Gzma-/-
mouse studies having informed our understanding of GZMA's physiological function. We …

The induction of adaptive immunological memory, mediated by T and B cells, plays an
important role in protective immunity to pathogens induced by previous infections or …

Tuberculosis (TB) remains a serious public health threat around the world. An effective
vaccine is urgently required for cost-effective, long-term control of TB. However, the only …

Objective Memory stem T (Tscm) cells are long‐lived, self‐renewing T cells that play a
relevant role in immunologic memory. This study was undertaken to investigate whether …

Abstract Background Recent Mycobacterium tuberculosis (M. tb) infection is associated with
a higher risk of progression to tuberculosis disease, compared to persistent infection after …