Ischemic stroke is one of the main causes of mortality and disability worldwide. However, the
majority of patients are currently unable to benefit from intravenous thrombolysis or …

Abstract The NACHT, LRR, and PYD domains‐containing protein 3 (NLRP3) inflammasome
is a multimolecular complex that plays a fundamental role in inflammation. Optimal activation …

The mechanisms underlying glucocorticoid (GC)-induced obesity are poorly understood.
Macrophages are the primary targets by which GCs exert pharmacological effects and …

Abstract Interleukin (IL)-1β is a culprit of adipose tissue inflammation, which in turn causes
systematic inflammation and insulin resistance in obese individuals. IL-1β is mainly …

Ferroptosis represents a novel non-apoptotic form of regulated cell death that is driven by
iron-dependent lipid peroxidation and plays vital roles in various diseases including …

Abstract Sirtuins (SIRTs), a NAD+ family of dependent deacetylases, are involved in the
regulation of various human diseases. Recently, accumulating evidence has uncovered …

Garcimultiflins A–C (1–3), three novel polycyclic polyprenylated acylphloroglucinols
(PPAPs), were isolated from the pericarps of Garcinia multiflora. Their structures and …

Twelve undescribed limonoids, meliazedarines J–U (1–12), along with a known one, were
isolated from the roots of Melia azedarach. Their structures were elucidated by extensive …

Obesity-related metabolic diseases are associated with a chronic inflammatory state.
Calenduloside E (CE) is a triterpene saponin from sugar beet. In mouse models, CE …

Cordyceps sinensis (CS) has been widely used as a dietary supplement or traditional
medicine for the prevention, treatment, and prognostication of various diseases, because of …