The melanocortin-4 receptor gene (MC4R) has intensively been analyzed in molecular
genetic obesity research. Decreased MC4R activity leads to obesity. Currently 166 …

Abstract Introduction Pathogenic heterozygous MC4R variants are associated with
hyperphagia and variable degrees of obesity. Several research groups have reported short …

Objective: To evaluate whether early childhood body mass index (BMI) is an appropriate
indicator for monogenic obesity. Methods: A cohort of n= 21 children living in Germany or …

Objective: We aimed to determine the prevalence of melanocortin-4 receptor (MC4R)
variants in a large German cohort of children with obesity in a pediatric outpatient clinic and …

Melanocortin 4 receptor gene plays an important role in food intake, energy balance, and
weight control. The autosomal dominantly inherited MC4R variants cause obesity by …

Several studies have shown that rs9939609 and rs1421085 in fat mass and obesity-
associated (FTO) gene rs17782313 and rs12970134 in melanocortin-4 receptor (MC4R) …

Mutations leading to a reduced function of the melanocortin-4 receptor (MC4R) exert a major
gene effect on extreme obesity. Recently it was shown that the bone derived hormone …

Objective: Melanocortin-4 receptor (MC4R) mutations are the most common known cause of
monogenic obesity. Data regarding MC4R mutations in Turkish subjects are limited. To …

Objectives Genetic factors have a key role in childhood obesity with higher rates in children
than adults. Among the monogenic types of non-syndromic obesity, melanocortin-4 receptor …

Zusammenfassung Hintergrund Monogene Adipositasformen haben eine geschätzte
Prävalenz von 1–5% in der Gruppe der extrem adipösen Patienten. Bereits im frühen …