mRNA vaccines for infectious diseases—advances, challenges and opportunities
The concept of mRNA-based vaccines emerged more than three decades ago.
Groundbreaking discoveries and technological advancements over the past 20 years have …
Groundbreaking discoveries and technological advancements over the past 20 years have …
Severe respiratory syncytial virus infection in children: burden, management, and emerging therapies
NI Mazur, MT Caballero, MC Nunes - The Lancet, 2024 - thelancet.com
The global burden of respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI)
in young children is high. The RSV prevention strategies approved in 2023 will be essential …
in young children is high. The RSV prevention strategies approved in 2023 will be essential …
[HTML][HTML] Use of respiratory syncytial virus vaccines in adults aged≥ 60 years: updated recommendations of the Advisory Committee on Immunization Practices …
A Britton - MMWR. Morbidity and mortality weekly report, 2024 - cdc.gov
Respiratory syncytial virus (RSV) is a major cause of respiratory illness and hospitalization
in older adults during fall and winter in the United States. The 2023–2024 RSV season was …
in older adults during fall and winter in the United States. The 2023–2024 RSV season was …
Transforming vaccinology
R Rappuoli, G Alter, B Pulendran - Cell, 2024 - cell.com
The COVID-19 pandemic placed the field of vaccinology squarely at the center of global
consciousness, emphasizing the vital role of vaccines as transformative public health tools …
consciousness, emphasizing the vital role of vaccines as transformative public health tools …
Rational formulation and industrial manufacturing of lipid-based complex injectables: Landmarks and trends
M Biscaia-Caleiras, NA Fonseca, AS Lourenço… - Journal of Controlled …, 2024 - Elsevier
Lipid-based complex injectables are renowned for their effectiveness in delivering drugs,
with many approved products. While significant strides have been made in formulating …
with many approved products. While significant strides have been made in formulating …
Advances in the design and delivery of RNA vaccines for infectious diseases
RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of
global significance, eg, infectious diseases. The highly successful messenger RNA (mRNA) …
global significance, eg, infectious diseases. The highly successful messenger RNA (mRNA) …
Humoral immunogenicity of mRNA-1345 RSV vaccine in older adults
J Goswami, AH Baqui, PA Doreski… - The Journal of …, 2024 - academic.oup.com
Background The mRNA-1345 vaccine demonstrated efficacy against respiratory syncytial
virus (RSV) disease with acceptable safety in adults aged≥ 60 years in the ConquerRSV …
virus (RSV) disease with acceptable safety in adults aged≥ 60 years in the ConquerRSV …
Respiratory syncytial virus infections in adults: a narrative review
JG Wildenbeest, DM Lowe, JF Standing… - The Lancet Respiratory …, 2024 - thelancet.com
Respiratory syncytial virus (RSV), an RNA virus spread by droplet infection that affects all
ages, is increasingly recognised as an important pathogen in adults, especially among older …
ages, is increasingly recognised as an important pathogen in adults, especially among older …
Safety and immunogenicity of mRNA-1010, an investigational seasonal influenza vaccine, in healthy adults: final results from a phase 1/2 randomized trial
J Ananworanich, IT Lee, D Ensz… - The Journal of …, 2024 - academic.oup.com
Background Seasonal influenza remains a global public health concern. A messenger RNA
(mRNA)–based quadrivalent seasonal influenza vaccine, mRNA-1010, was investigated in …
(mRNA)–based quadrivalent seasonal influenza vaccine, mRNA-1010, was investigated in …
Longitudinal humoral analysis in RSV-infected infants identifies pre-existing RSV strain-specific G and evolving cross-reactive F antibodies
Respiratory syncytial virus (RSV) is among the most common causes of lower respiratory
tract infection (LRTI) and hospitalization in infants. However, the mechanisms of immune …
tract infection (LRTI) and hospitalization in infants. However, the mechanisms of immune …