With the increasing world population, demand for industrialization has also increased to
fulfill humans' living standards. Fungi are considered a source of essential constituents to …

The 3-chymotrypsin-like cysteine protease (3CLpro) of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is considered a major target for the discovery of direct antiviral …

Cathepsin B is a lysosomal protease that participates in protein degradation. However,
cathepsin B is also active under neutral pH conditions of the cytosol, nuclei, and …

Excessive activities of cysteinyl cathepsins (CysCts) contribute to the progress of many
diseases; however, therapeutic inhibition has been problematic. Zn 2+ is a natural inhibitor …

Addressing the elusive specificity of cysteine cathepsins, which in contrast to caspases and
trypsin-like proteases lack strict specificity determining P1 pocket, calls for innovative …

Proteolysis is a central regulator of many biological pathways and the study of proteases has
had a significant impact on our understanding of both native biology and disease. Proteases …

Fasciola hepatica is a trematode parasite that causes fasciolosis in animals and humans.
Fasciolosis is usually treated with triclabendazole, although drug-resistant parasites have …

Triple‐negative breast cancer (TNBC) patients harboring wild‐type breast cancer
susceptibility gene 1 (BRCA1) account for most TNBC patients but lack adequate targeted …

Fasciola hepatica is a parasitic trematode that infects livestock animals and humans,
causing significant health and economic burdens worldwide. The extensive use of …

Independent trials indicate that either oral Zn2+ or metformin can separately improve COVID-
19 outcomes by approximately 40%. Coordination chemistry predicts a mechanistic …